Some supplementary files for the hovlinc paper:
Yue Chen#, Fei Qi#*, Fan Gao, Huifen Cao, Dongyang Xu, Kourosh Salehi-Ashtiani, and Philipp Kapranov*. Hovlinc is a recently evolved class of ribozyme found in human lncRNA. Nat Chem Biol 17(5), 601–607 (2021). https://doi.org/10.1038/s41589-021-00763-0
Multiple sequence alignments:
MSA_all_homologs.fa
: alignment of human hovlinc and 75 homologous sequencesMSA_hominins.fa
: alignment of the 3 active sequences from human, chimpanzee and bonobo
Descriptors of the RNA sequence-structure patterns of some known ribozyme classes. These descriptors were used as input to the RNAMotif program to check whether hovlinc ribozyme is an instance of these known ribozymes.
R code for calculating the kobs and pKa of hovlinc ribozyme.