Intermediate data and analysis tools from Scher et al., eLife, 2013
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Figure 1. Differences in the relative abundance of Prevotella and Bacteroides in 114 subjects with and without arthritis, determined by 16S sequencing (regions V1-V2, 454 platform).
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Figure 1 - supplement 1. Gut microbiota richness, diversity and relative abundance in NORA patients and controls.
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Figure 2. Homology-based classification of patient-associated Prevotella.
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Figure 2 - supplement 1. 16S based classification of patient-associated Prevotella.
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Figure 3. Comparison of P. copri genomes from healthy and NORA subjects.
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Figure 3 – supplement 1. Recovery of Prevotella copri pangenome from HMP/RA shotgun reads and determination of presence/absence of P. copri ORFs by alignment of reads to pangenome gene catalog.
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Figure 3 – supplement 2. Metagenomic context of discriminative biomarker ORFs.
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Figure 4. Metabolic pathway representation in the microbiome of healthy and NORA subjects.
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Figure 5. Relationship of host HLA genotype to abundance of Prevotella copri (OTU4, OTU12, and OTU934 combined relative abundance).
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Figure 6. Colonization with P. copri dominates the colonic microbiome and exacerbates local and systemic inflammatory responses.
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Figure 6 – supplement 1. P. copri colonization exacerbates chemically induced colitis.