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Simplify derivatives #34

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merged 4 commits into from
Nov 13, 2018

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martin-gmx
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Hi Andy.
These changes should allow us to more easily add other forms of derivatives.

II am still trying to get my head around this double derivatives - that we take the derivative of v wrt all parameters, but v already linearizes (i.e., takes the derivative of all parameters). Couldn't we try to use the chain rule and remove this multiplication of derivatives?

Cheers
Martin

@mattfidler
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Hi @andrewhooker and @martin-gmx ; Does this imply you need to use deSolve; I was working something out with nlmixr that integrates with PopED, but uses RxODE. I haven't tested it but will abandon it if you require deSolve

@Sibojang9
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My personal experience is that RxODE is much easier to use than deSolve. I would vote for PopED+RxODE.

@andrewhooker
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andrewhooker commented Nov 1, 2018 via email

@martin-gmx
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martin-gmx commented Nov 3, 2018

The user provides the model solution - and in the future we will (hopefully) be able to use also the partial derivatives of the solution w.r.t. the model parameters, if the user provides them.

@mattfidler
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mattfidler commented Nov 3, 2018 via email

@andrewhooker andrewhooker merged commit d8764de into andrewhooker:master Nov 13, 2018
@andrewhooker
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Looks good Martin!

@martin-gmx martin-gmx deleted the SimplifyDerivatives branch December 20, 2018 16:53
@martin-gmx martin-gmx restored the SimplifyDerivatives branch March 31, 2020 10:23
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4 participants