Skip to content

Commit

Permalink
Add Nahyung to spatial community analysis project
Browse files Browse the repository at this point in the history
  • Loading branch information
althonos committed Feb 19, 2024
1 parent 0999220 commit db7a5b5
Showing 1 changed file with 2 additions and 2 deletions.
4 changes: 2 additions & 2 deletions projects/_posts/2023-11-01-spatial-community-analysis.md
Original file line number Diff line number Diff line change
@@ -1,7 +1,7 @@
---
layout: project
title: "Spatial community analysis"
contributors: [nkarcher, shitut]
contributors: [nkarcher, shitut, nko]
handle: spatial
status: ongoing
type: dataset
Expand All @@ -24,4 +24,4 @@ osf:
---
{% include JB/setup %}

The culture-independent study of microbial communities has been driven by metagenomic sequencing. While this can reveal overall bacterial community composition, all spatial information is generally lost during DNA extraction. However, the spatial organisation of microbial communities is key to their function. Consequently, a better mechanistic understanding of microbe-microbe and microbe-host interactions critically depends on the availability of spatial technologies. In our group we are developing a multiplexed FISH-based assay to detect different bacteria simultaneously in situ. We are currently primarily applying this technology to understand the spatial architecture of bacterial communities in colorectal tumour tissue and how this shapes their interactions with tumour and immune cell populations.
The culture-independent study of microbial communities has been driven by metagenomic sequencing. While this can reveal overall bacterial community composition, all spatial information is generally lost during DNA extraction. However, the spatial organisation of microbial communities is key to their function. Consequently, a better mechanistic understanding of microbe-microbe and microbe-host interactions critically depends on the availability of spatial technologies. In our group we are developing a multiplexed FISH-based assay to detect different bacteria simultaneously in situ. We are currently primarily applying this technology to understand the spatial architecture of bacterial communities in colorectal tumour tissue and how this shapes their interactions with tumour and immune cell populations.

0 comments on commit db7a5b5

Please sign in to comment.