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PFS and OS curves crossing #360

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william-rawlinson opened this issue Jun 5, 2023 · 2 comments
Open

PFS and OS curves crossing #360

william-rawlinson opened this issue Jun 5, 2023 · 2 comments

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@william-rawlinson
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It would be great to have a work around for when PFS and OS curves cross when using heemod for a partitioned survival model. Currently, this causes an error 'Error in compute_counts.eval_part_surv(x = transition, init = init, inflow = inflow): Negative counts in partitioned survival model, at cycles: 1, 2, etc.'

Sometimes, the best fit for the PFS and OS curves will cross. In this case, the progressed disease state occupancy should be calculated as max(0, overall survival - progression free survival).
@KZARCA
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KZARCA commented Jun 6, 2023

Hi, can you please repost this issue in the new heemod repository (aphp/heemod)?
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@william-rawlinson
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Thanks - will do!

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@KZARCA @william-rawlinson