11-Guidance-Recommendations.Rmd

# Guidance on Applying Covariate Adjustment {#recommendations}

## Relevant Regulatory Guidance




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## Missing Covariates

  - How much missingness is too much
  - Approaches and justification for missing covariates
  - Preserving independence of covariates and treatment




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## Statistical Analysis Plans




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## Sample size for adjusted vs. unadjusted




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## Number of parameters vs. sample size


  - Adjusting for sites in multi-site trial



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## Data-Adaptive Covariate Adjustment