diff --git a/packages/plugin-react/src/jsx-runtime/restore-jsx.ts b/packages/plugin-react/src/jsx-runtime/restore-jsx.ts
index 0d4f34eb2b8d00..250fe43ce4d0c8 100644
--- a/packages/plugin-react/src/jsx-runtime/restore-jsx.ts
+++ b/packages/plugin-react/src/jsx-runtime/restore-jsx.ts
@@ -4,15 +4,23 @@ type RestoredJSX = [result: t.File | null | undefined, isCommonJS: boolean]
 
 let babelRestoreJSX: Promise<PluginItem> | undefined
 
+const jsxNotFound: RestoredJSX = [null, false]
+
 /** Restore JSX from `React.createElement` calls */
 export async function restoreJSX(
   babel: typeof import('@babel/core'),
   code: string,
   filename: string
 ): Promise<RestoredJSX> {
+  // Avoid parsing the optimized react-dom since it will never
+  // contain compiled JSX and it's a pretty big file (800kb).
+  if (filename.includes('/.vite/react-dom.js')) {
+    return jsxNotFound
+  }
+
   const [reactAlias, isCommonJS] = parseReactAlias(code)
   if (!reactAlias) {
-    return [null, false]
+    return jsxNotFound
   }
 
   const reactJsxRE = new RegExp(
@@ -28,7 +36,7 @@ export async function restoreJSX(
   })
 
   if (!hasCompiledJsx) {
-    return [null, false]
+    return jsxNotFound
   }
 
   // Support modules that use `import {Fragment} from 'react'`