diff --git a/SofaKernel/cmake/CompilerOptions.cmake b/SofaKernel/cmake/CompilerOptions.cmake
index 49f7b289b52..d68189622a8 100644
--- a/SofaKernel/cmake/CompilerOptions.cmake
+++ b/SofaKernel/cmake/CompilerOptions.cmake
@@ -48,18 +48,6 @@ if(APPLE)
     set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -DGL_SILENCE_DEPRECATION")
 endif()
 
-## SOFA_DEBUG preprocessor macro
-if(WIN32 OR APPLE)
-    # Reminder: multi-configuration generators like Visual Studio and XCode do
-    # not use CMAKE_BUILD_TYPE, as they generate all configurations in the
-    # project, not just one at a time!
-    set(CMAKE_C_FLAGS_DEBUG "${CMAKE_C_FLAGS_DEBUG} -DSOFA_DEBUG")
-    set(CMAKE_CXX_FLAGS_DEBUG "${CMAKE_CXX_FLAGS_DEBUG} -DSOFA_DEBUG")
-elseif(CMAKE_BUILD_TYPE MATCHES "Debug")
-    add_definitions("-DSOFA_DEBUG")
-endif()
-
-
 
 ## OpenMP
 option(SOFA_OPENMP "Compile Sofa with OpenMP multithreading." OFF)
diff --git a/SofaKernel/modules/SofaBaseMechanics/MechanicalObject.inl b/SofaKernel/modules/SofaBaseMechanics/MechanicalObject.inl
index f6e2f1b8e84..46efec3d7d6 100644
--- a/SofaKernel/modules/SofaBaseMechanics/MechanicalObject.inl
+++ b/SofaKernel/modules/SofaBaseMechanics/MechanicalObject.inl
@@ -1501,7 +1501,7 @@ Data<typename MechanicalObject<DataTypes>::VecCoord>* MechanicalObject<DataTypes
         }
     }
     Data<typename MechanicalObject<DataTypes>::VecCoord>* d = vectorsCoord[v.index];
-#if defined(SOFA_DEBUG) || !defined(NDEBUG)
+#if !defined(NDEBUG)
     const typename MechanicalObject<DataTypes>::VecCoord& val = d->getValue();
     if (!val.empty() && val.size() != (unsigned int)this->getSize())
     {
@@ -1524,7 +1524,7 @@ const Data<typename MechanicalObject<DataTypes>::VecCoord>* MechanicalObject<Dat
     if (v.index < vectorsCoord.size() && vectorsCoord[v.index] != nullptr)
     {
         const Data<typename MechanicalObject<DataTypes>::VecCoord>* d = vectorsCoord[v.index];
-#if defined(SOFA_DEBUG) || !defined(NDEBUG)
+#if !defined(NDEBUG)
         const typename MechanicalObject<DataTypes>::VecCoord& val = d->getValue();
         if (!val.empty() && val.size() != (unsigned int)this->getSize())
         {
@@ -1568,7 +1568,7 @@ Data<typename MechanicalObject<DataTypes>::VecDeriv>* MechanicalObject<DataTypes
     }
     Data<typename MechanicalObject<DataTypes>::VecDeriv>* d = vectorsDeriv[v.index];
 
-#if defined(SOFA_DEBUG) || !defined(NDEBUG)
+#if !defined(NDEBUG)
     const typename MechanicalObject<DataTypes>::VecDeriv& val = d->getValue();
     if (!val.empty() && val.size() != (unsigned int)this->getSize())
     {
@@ -1586,7 +1586,7 @@ const Data<typename MechanicalObject<DataTypes>::VecDeriv>* MechanicalObject<Dat
     {
         const Data<typename MechanicalObject<DataTypes>::VecDeriv>* d = vectorsDeriv[v.index];
 
-#if defined(SOFA_DEBUG) || !defined(NDEBUG)
+#if !defined(NDEBUG)
         const typename MechanicalObject<DataTypes>::VecDeriv& val = d->getValue();
         if (!val.empty() && val.size() != (unsigned int)this->getSize())
         {