diff --git a/docs/changelog.rst b/docs/changelog.rst
index d1a3bd5..e432c63 100644
--- a/docs/changelog.rst
+++ b/docs/changelog.rst
@@ -4,6 +4,7 @@ Changelog
 1.1.0 (unreleased)
 ------------------
 
+- #25 Do not allow to "submit" AST analyses with no result save
 - #23 Fix AST calculation does not work when extrapolated antibiotics
 - #22 Hide Unit and display Submitter before Captured in AST entry
 - #21 Fix AST entry is empty when analyses categorization for sample is checked
diff --git a/src/senaite/ast/adapters/guards.py b/src/senaite/ast/adapters/guards.py
index c679df0..d8ad495 100644
--- a/src/senaite/ast/adapters/guards.py
+++ b/src/senaite/ast/adapters/guards.py
@@ -89,20 +89,26 @@ def guard_submit(self):
             # Not an AST analysis
             return True
 
-        # Check that all interim fields have non-empty values
-        keyword = self.context.getKeyword()
-        for interim in self.context.getInterimFields():
+        # Get the antibiotics (as interim fields)
+        antibiotics = self.context.getInterimFields()
+        if not antibiotics:
+            return False
 
-            if utils.is_extrapolated_interim(interim):
-                # Skip extrapolated interims
+        keyword = self.context.getKeyword()
+        for antibiotic in antibiotics:
+            if utils.is_extrapolated_interim(antibiotic):
+                # Skip extrapolated antibiotics
                 continue
 
+            if utils.is_interim_empty(antibiotic):
+                # Cannot submit if no result
+                return False
+
             if keyword in [ZONE_SIZE_KEY, DISK_CONTENT_KEY]:
                 # Negative values are not permitted
-                value = interim.get("value")
+                value = antibiotic.get("value")
                 value = api.to_float(value, default=-1)
                 if value < 0:
                     return False
 
-        # No empties
         return True