diff --git a/Lib/test/test_compile.py b/Lib/test/test_compile.py
index a5434d6fd512ed..85f05a8dd257f4 100644
--- a/Lib/test/test_compile.py
+++ b/Lib/test/test_compile.py
@@ -1215,7 +1215,6 @@ def test_multiline_boolean_expression(self):
         d > 0)):
     x = 42
 """
-
         compiled_code, _ = self.check_positions_against_ast(snippet)
         # jump if a is true:
         self.assertOpcodeSourcePositionIs(compiled_code, 'POP_JUMP_IF_TRUE',
@@ -1233,6 +1232,23 @@ def test_multiline_boolean_expression(self):
         self.assertOpcodeSourcePositionIs(compiled_code, 'POP_JUMP_IF_TRUE',
             line=4, end_line=4, column=8, end_column=13, occurrence=2)
 
+    def test_multiline_assert(self):
+        snippet = """\
+assert (a > 0 and
+        bb > 0 and
+        ccc == 4), "error msg"
+"""
+        compiled_code, _ = self.check_positions_against_ast(snippet)
+        self.assertOpcodeSourcePositionIs(compiled_code, 'LOAD_ASSERTION_ERROR',
+            line=1, end_line=3, column=0, end_column=30, occurrence=1)
+        #  The "error msg":
+        self.assertOpcodeSourcePositionIs(compiled_code, 'LOAD_CONST',
+            line=3, end_line=3, column=19, end_column=30, occurrence=4)
+        self.assertOpcodeSourcePositionIs(compiled_code, 'CALL',
+            line=1, end_line=3, column=0, end_column=30, occurrence=1)
+        self.assertOpcodeSourcePositionIs(compiled_code, 'RAISE_VARARGS',
+            line=1, end_line=3, column=0, end_column=30, occurrence=1)
+
     def test_very_long_line_end_offset(self):
         # Make sure we get the correct column offset for offsets
         # too large to store in a byte.
diff --git a/Misc/NEWS.d/next/Core and Builtins/2022-10-18-16-17-44.gh-issue-98398.x4rYK_.rst b/Misc/NEWS.d/next/Core and Builtins/2022-10-18-16-17-44.gh-issue-98398.x4rYK_.rst
new file mode 100644
index 00000000000000..35d33c90a6902b
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2022-10-18-16-17-44.gh-issue-98398.x4rYK_.rst	
@@ -0,0 +1 @@
+Fix source location of 'assert' bytecodes.
diff --git a/Python/compile.c b/Python/compile.c
index 4d5b41aa13003c..c888f4064c79da 100644
--- a/Python/compile.c
+++ b/Python/compile.c
@@ -3960,7 +3960,6 @@ compiler_from_import(struct compiler *c, stmt_ty s)
 static int
 compiler_assert(struct compiler *c, stmt_ty s)
 {
-    location loc = LOC(s);
     /* Always emit a warning if the test is a non-zero length tuple */
     if ((s->v.Assert.test->kind == Tuple_kind &&
         asdl_seq_LEN(s->v.Assert.test->v.Tuple.elts) > 0) ||
@@ -3968,23 +3967,26 @@ compiler_assert(struct compiler *c, stmt_ty s)
          PyTuple_Check(s->v.Assert.test->v.Constant.value) &&
          PyTuple_Size(s->v.Assert.test->v.Constant.value) > 0))
     {
-        if (!compiler_warn(c, loc, "assertion is always true, "
-                                   "perhaps remove parentheses?"))
+        if (!compiler_warn(c, LOC(s), "assertion is always true, "
+                                      "perhaps remove parentheses?"))
         {
             return 0;
         }
     }
-    if (c->c_optimize)
+    if (c->c_optimize) {
         return 1;
+    }
     NEW_JUMP_TARGET_LABEL(c, end);
-    if (!compiler_jump_if(c, &loc, s->v.Assert.test, end, 1))
+    location loc = LOC(s);
+    if (!compiler_jump_if(c, &loc, s->v.Assert.test, end, 1)) {
         return 0;
-    ADDOP(c, loc, LOAD_ASSERTION_ERROR);
+    }
+    ADDOP(c, LOC(s), LOAD_ASSERTION_ERROR);
     if (s->v.Assert.msg) {
         VISIT(c, expr, s->v.Assert.msg);
-        ADDOP_I(c, loc, CALL, 0);
+        ADDOP_I(c, LOC(s), CALL, 0);
     }
-    ADDOP_I(c, loc, RAISE_VARARGS, 1);
+    ADDOP_I(c, LOC(s), RAISE_VARARGS, 1);
 
     USE_LABEL(c, end);
     return 1;