diff --git a/CHANGELOG.md b/CHANGELOG.md
index 77ea5edf21..54a3f40184 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -9,6 +9,7 @@
 - [docs] Add more examples
 - [dev] Change github action job names
 - [docs] Add additional examples for installation from git repos
+- [packaging] Switch to [PEP 621](https://www.python.org/dev/peps/pep-0621/)
 
 ## 1.0.0
 
diff --git a/MANIFEST.in b/MANIFEST.in
deleted file mode 100644
index 4351b0e610..0000000000
--- a/MANIFEST.in
+++ /dev/null
@@ -1,14 +0,0 @@
-graft src
-include *.md pipx_demo.gif logo.png LICENSE
-
-exclude .isort.cfg .pre-commit-config.yaml get-pipx.py makefile generate_docs.py .flake8 mkdocs.yml noxfile.py .coveragerc .deepsource.toml
-recursive-exclude testdata *
-
-prune templates
-prune tests
-prune docs
-prune scripts
-
-global-exclude *.py[cod]
-global-exclude __pycache__
-global-exclude .*.swp
diff --git a/noxfile.py b/noxfile.py
index e1101406a6..4c04ca64b3 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -14,7 +14,6 @@
     "flake8-bugbear==21.11.29",
     "mypy==0.930",
     "types-jinja2",
-    "check-manifest==0.47",
     "packaging>=20.0",
     "isort==5.10.1",
 ]
@@ -173,8 +172,6 @@ def lint(session):
         "--warn-unused-ignores",
         *files,
     )
-    session.run("check-manifest")
-    session.run("python", "setup.py", "check", "--metadata", "--strict")
 
 
 @nox.session(python=PYTHON_ALL_VERSIONS)
diff --git a/pyproject.toml b/pyproject.toml
index 3198dd9257..6167b80847 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,15 +1,55 @@
 [build-system]
-requires = ["setuptools", "wheel"]
-build-backend = "setuptools.build_meta"
+requires = ["hatchling>=0.15.0"]
+build-backend = "hatchling.build"
+
+[project]
+name = "pipx"
+description = "Install and Run Python Applications in Isolated Environments"
+readme = "README.md"
+license = "MIT"
+requires-python = ">=3.7"
+keywords = ["pip", "install", "cli", "workflow", "Virtual Environment"]
+authors = [{ name = "Chad Smith", email = "chadsmith.software@gmail.com" }]
+classifiers = [
+  "License :: OSI Approved :: MIT License",
+  "Operating System :: OS Independent",
+  "Programming Language :: Python",
+  "Programming Language :: Python :: 3 :: Only",
+  "Programming Language :: Python :: 3.7",
+  "Programming Language :: Python :: 3.8",
+  "Programming Language :: Python :: 3.9",
+  "Programming Language :: Python :: 3.10",
+]
+dependencies = [
+  "argcomplete>=1.9.4",
+  "colorama>=0.4.4; sys_platform == 'win32'",
+  "importlib-metadata>=3.3.0; python_version < '3.8'",
+  "packaging>=20.0",
+  "userpath>=1.6.0",
+]
+dynamic = ["version"]
+
+[project.urls]
+Documentation = "https://pypa.github.io/pipx/"
+"Source Code" = "https://github.com/pypa/pipx"
+"Bug Tracker" = "https://github.com/pypa/pipx/issues"
+
+[project.scripts]
+pipx = "pipx.main:cli"
+
+[tool.hatch.version]
+source = "code"
+path = "src/pipx/version.py"
+
+[tool.hatch.build.targets.sdist]
+include = ["/src", "/logo.png", "/pipx_demo.gif", "/*.md"]
 
 [tool.isort]
 profile = "black"
 known_first_party = ["helpers", "package_info"]
 
 [tool.pytest.ini_options]
-markers = [
-    "all_packages: test install with maximum number of packages",
-]
+markers = ["all_packages: test install with maximum number of packages"]
 
 [tool.black]
 skip-magic-trailing-comma = true
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 5c1641fccf..0000000000
--- a/setup.cfg
+++ /dev/null
@@ -1,45 +0,0 @@
-[metadata]
-name = pipx
-version = attr: pipx.version.__version__
-author = Chad Smith
-author_email = Chad Smith <chadsmith.software@gmail.com>
-description = Install and Run Python Applications in Isolated Environments
-long_description = file: README.md
-long_description_content_type = text/markdown
-url = https://github.com/pypa/pipx
-project_urls =
-    Documentation = https://pypa.github.io/pipx/
-    Source Code = https://github.com/pypa/pipx
-    Bug Tracker = https://github.com/pypa/pipx/issues
-keywords = pip, install, cli, workflow, Virtual Environment
-license = License :: OSI Approved :: MIT License
-classifiers =
-    Operating System :: OS Independent
-    License :: OSI Approved :: MIT License
-    Programming Language :: Python
-    Programming Language :: Python :: 3.7
-    Programming Language :: Python :: 3.8
-    Programming Language :: Python :: 3.9
-    Programming Language :: Python :: 3.10
-    Programming Language :: Python :: 3 :: Only
-
-[options]
-packages = find:
-package_dir =
-    = src
-include_package_data = true
-zip_safe = true
-python_requires = >=3.6
-install_requires =
-    colorama>=0.4.4;sys_platform=="win32"
-    userpath>=1.6.0
-    argcomplete>=1.9.4
-    packaging>=20.0
-    importlib-metadata>=3.3.0; python_version < '3.8'
-
-[options.packages.find]
-where = src
-
-[options.entry_points]
-console_scripts =
-    pipx = pipx.main:cli
diff --git a/setup.py b/setup.py
deleted file mode 100755
index 4024e697e5..0000000000
--- a/setup.py
+++ /dev/null
@@ -1,14 +0,0 @@
-#!/usr/bin/env python3
-
-import sys
-
-from setuptools import setup  # type: ignore
-
-if sys.version_info < (3, 6, 0):
-    sys.exit(
-        "Python 3.6 or later is required. "
-        "See https://github.com/pypa/pipx "
-        "for installation instructions."
-    )
-
-setup()