diff --git a/lib/internal/loader/ModuleRequest.js b/lib/internal/loader/ModuleRequest.js
index 13606568c3309d..93baf2a597fc1a 100644
--- a/lib/internal/loader/ModuleRequest.js
+++ b/lib/internal/loader/ModuleRequest.js
@@ -36,9 +36,12 @@ loaders.set('esm', async (url) => {
 });
 
 // Strategy for loading a node-style CommonJS module
+const isWindows = process.platform === 'win32';
+const winSepRegEx = /\//g;
 loaders.set('cjs', async (url) => {
   const pathname = internalURLModule.getPathFromURL(new URL(url));
-  const module = CJSModule._cache[pathname];
+  const module = CJSModule._cache[
+      isWindows ? pathname.replace(winSepRegEx, '\\') : pathname];
   if (module && module.loaded) {
     const ctx = createDynamicModule(['default'], url, undefined);
     ctx.reflect.exports.default.set(module.exports);