diff --git a/apps/settings/lib/SetupChecks/PhpOpcacheSetup.php b/apps/settings/lib/SetupChecks/PhpOpcacheSetup.php
index e3cf4659dbef8..22605012058b1 100644
--- a/apps/settings/lib/SetupChecks/PhpOpcacheSetup.php
+++ b/apps/settings/lib/SetupChecks/PhpOpcacheSetup.php
@@ -114,6 +114,11 @@ protected function getOpcacheSetupRecommendations(): array {
 	}
 
 	public function run(): SetupResult {
+		// Skip OPcache checks if running from CLI
+		if (\OC::$CLI && !$this->iniGetWrapper->getBool('opcache.enable_cli')) {
+			return SetupResult::success($this->l10n->t('Checking from CLI, OPcache checks have been skipped.'));
+		}
+
 		[$level,$recommendations] = $this->getOpcacheSetupRecommendations();
 		if (!empty($recommendations)) {
 			return match($level) {