diff --git a/src/display/editor/editor.js b/src/display/editor/editor.js
index 187c3526c5332..300d8a9d2d589 100644
--- a/src/display/editor/editor.js
+++ b/src/display/editor/editor.js
@@ -74,6 +74,8 @@ class AnnotationEditor {
     } = this.parent.viewport;
 
     this.rotation = rotation;
+    this.pageRotation =
+      (360 + rotation - this._uiManager.viewParameters.rotation) % 360;
     this.pageDimensions = [pageWidth, pageHeight];
     this.pageTranslation = [pageX, pageY];
 
@@ -250,7 +252,7 @@ class AnnotationEditor {
   }
 
   get parentRotation() {
-    return this._uiManager.viewParameters.rotation;
+    return (this._uiManager.viewParameters.rotation + this.pageRotation) % 360;
   }
 
   get parentDimensions() {
diff --git a/test/integration/ink_editor_spec.js b/test/integration/ink_editor_spec.js
index 9b92d777372b6..7a40d250b282c 100644
--- a/test/integration/ink_editor_spec.js
+++ b/test/integration/ink_editor_spec.js
@@ -19,8 +19,8 @@ const {
   loadAndWait,
 } = require("./test_utils.js");
 
-describe("Editor", () => {
-  describe("Ink", () => {
+describe("Ink Editor", () => {
+  describe("Basic operations", () => {
     let pages;
 
     beforeAll(async () => {
@@ -135,4 +135,51 @@ describe("Editor", () => {
       );
     });
   });
+
+  describe("with a rotated pdf", () => {
+    let pages;
+
+    beforeAll(async () => {
+      pages = await loadAndWait("issue16278.pdf", ".annotationEditorLayer");
+    });
+
+    afterAll(async () => {
+      await closePages(pages);
+    });
+
+    it("must draw something", async () => {
+      await Promise.all(
+        pages.map(async ([browserName, page]) => {
+          await page.click("#editorInk");
+
+          const rect = await page.$eval(".annotationEditorLayer", el => {
+            // With Chrome something is wrong when serializing a DomRect,
+            // hence we extract the values and just return them.
+            const { x, y } = el.getBoundingClientRect();
+            return { x, y };
+          });
+
+          const x = rect.x + 20;
+          const y = rect.y + 20;
+          await page.mouse.move(x, y);
+          await page.mouse.down();
+          await page.mouse.move(x + 50, y + 50);
+          await page.mouse.up();
+
+          await page.waitForTimeout(10);
+          await page.keyboard.press("Escape");
+          await page.waitForTimeout(10);
+
+          await page.keyboard.down("Control");
+          await page.keyboard.press("a");
+          await page.keyboard.up("Control");
+          await page.waitForTimeout(10);
+
+          expect(await getSelectedEditors(page))
+            .withContext(`In ${browserName}`)
+            .toEqual([0]);
+        })
+      );
+    });
+  });
 });
diff --git a/test/pdfs/.gitignore b/test/pdfs/.gitignore
index 08047ff9b865a..b9e823515fc60 100644
--- a/test/pdfs/.gitignore
+++ b/test/pdfs/.gitignore
@@ -584,3 +584,4 @@
 !bug1820909.1.pdf
 !issue16221.pdf
 !issue16224.pdf
+!issue16278.pdf
diff --git a/test/pdfs/issue16278.pdf b/test/pdfs/issue16278.pdf
new file mode 100644
index 0000000000000..270b9826d21fd
Binary files /dev/null and b/test/pdfs/issue16278.pdf differ