diff --git a/packages/react-native-renderer/src/ReactFabric.js b/packages/react-native-renderer/src/ReactFabric.js
index 1e3d299ece9e8..4ec730a3f9a5e 100644
--- a/packages/react-native-renderer/src/ReactFabric.js
+++ b/packages/react-native-renderer/src/ReactFabric.js
@@ -44,6 +44,11 @@ import {LegacyRoot, ConcurrentRoot} from 'react-reconciler/src/ReactRootTags';
 import ReactSharedInternals from 'shared/ReactSharedInternals';
 import getComponentNameFromType from 'shared/getComponentNameFromType';
 
+const {
+  dispatchCommand: fabricDispatchCommand,
+  sendAccessibilityEvent: fabricSendAccessibilityEvent,
+} = nativeFabricUIManager;
+
 const ReactCurrentOwner = ReactSharedInternals.ReactCurrentOwner;
 
 function findHostInstance_DEPRECATED<TElementType: ElementType>(
@@ -168,7 +173,7 @@ function dispatchCommand(handle: any, command: string, args: Array<any>) {
   if (handle._internalInstanceHandle != null) {
     const {stateNode} = handle._internalInstanceHandle;
     if (stateNode != null) {
-      nativeFabricUIManager.dispatchCommand(stateNode.node, command, args);
+      fabricDispatchCommand(stateNode.node, command, args);
     }
   } else {
     UIManager.dispatchViewManagerCommand(handle._nativeTag, command, args);
@@ -189,7 +194,7 @@ function sendAccessibilityEvent(handle: any, eventType: string) {
   if (handle._internalInstanceHandle != null) {
     const {stateNode} = handle._internalInstanceHandle;
     if (stateNode != null) {
-      nativeFabricUIManager.sendAccessibilityEvent(stateNode.node, eventType);
+      fabricSendAccessibilityEvent(stateNode.node, eventType);
     }
   } else {
     legacySendAccessibilityEvent(handle._nativeTag, eventType);
diff --git a/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js b/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js
index c4c6eaa22a483..579c8de687387 100644
--- a/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js
+++ b/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js
@@ -10,6 +10,8 @@
 // Module provided by RN:
 import {UIManager} from 'react-native/Libraries/ReactPrivate/ReactNativePrivateInterface';
 
+const {setIsJSResponder} = nativeFabricUIManager;
+
 const ReactFabricGlobalResponderHandler = {
   onChange: function(from: any, to: any, blockNativeResponder: boolean) {
     const fromOrTo = from || to;
@@ -21,7 +23,7 @@ const ReactFabricGlobalResponderHandler = {
     if (isFabric) {
       if (from) {
         // equivalent to clearJSResponder
-        nativeFabricUIManager.setIsJSResponder(
+        setIsJSResponder(
           from.stateNode.node,
           false,
           blockNativeResponder || false,
@@ -30,7 +32,7 @@ const ReactFabricGlobalResponderHandler = {
 
       if (to) {
         // equivalent to setJSResponder
-        nativeFabricUIManager.setIsJSResponder(
+        setIsJSResponder(
           to.stateNode.node,
           true,
           blockNativeResponder || false,
diff --git a/packages/react-native-renderer/src/ReactNativeFiberInspector.js b/packages/react-native-renderer/src/ReactNativeFiberInspector.js
index 4bc374bc772e4..14545550647dd 100644
--- a/packages/react-native-renderer/src/ReactNativeFiberInspector.js
+++ b/packages/react-native-renderer/src/ReactNativeFiberInspector.js
@@ -26,6 +26,8 @@ if (__DEV__) {
   Object.freeze(emptyObject);
 }
 
+const {measure, findNodeAtPoint} = nativeFabricUIManager;
+
 let createHierarchy;
 let getHostNode;
 let getHostProps;
@@ -53,7 +55,7 @@ if (__DEV__ || enableGetInspectorDataForInstanceInProduction) {
               hostFiber.stateNode.node;
 
             if (shadowNode) {
-              nativeFabricUIManager.measure(shadowNode, callback);
+              measure(shadowNode, callback);
             } else {
               return UIManager.measure(
                 getHostNode(fiber, findNodeHandle),
@@ -195,7 +197,7 @@ if (__DEV__) {
 
     if (inspectedView._internalInstanceHandle != null) {
       // For Fabric we can look up the instance handle directly and measure it.
-      nativeFabricUIManager.findNodeAtPoint(
+      findNodeAtPoint(
         inspectedView._internalInstanceHandle.stateNode.node,
         locationX,
         locationY,
@@ -215,7 +217,7 @@ if (__DEV__) {
           const nativeViewTag =
             internalInstanceHandle.stateNode.canonical._nativeTag;
 
-          nativeFabricUIManager.measure(
+          measure(
             internalInstanceHandle.stateNode.node,
             (x, y, width, height, pageX, pageY) => {
               const inspectorData = getInspectorDataForInstance(
diff --git a/packages/react-native-renderer/src/ReactNativeRenderer.js b/packages/react-native-renderer/src/ReactNativeRenderer.js
index d9577a6eb6d58..85e8a1436a9f4 100644
--- a/packages/react-native-renderer/src/ReactNativeRenderer.js
+++ b/packages/react-native-renderer/src/ReactNativeRenderer.js
@@ -49,6 +49,11 @@ import getComponentNameFromType from 'shared/getComponentNameFromType';
 
 const ReactCurrentOwner = ReactSharedInternals.ReactCurrentOwner;
 
+const {
+  sendAccessibilityEvent: fabricSendAccessibilityEvent,
+  dispatchCommand: fabricDispatchCommand,
+} = nativeFabricUIManager;
+
 function findHostInstance_DEPRECATED(
   componentOrHandle: any,
 ): ?React$ElementRef<HostComponent<mixed>> {
@@ -165,7 +170,7 @@ function dispatchCommand(handle: any, command: string, args: Array<any>) {
   if (handle._internalInstanceHandle != null) {
     const {stateNode} = handle._internalInstanceHandle;
     if (stateNode != null) {
-      nativeFabricUIManager.dispatchCommand(stateNode.node, command, args);
+      fabricDispatchCommand(stateNode.node, command, args);
     }
   } else {
     UIManager.dispatchViewManagerCommand(handle._nativeTag, command, args);
@@ -186,7 +191,7 @@ function sendAccessibilityEvent(handle: any, eventType: string) {
   if (handle._internalInstanceHandle != null) {
     const {stateNode} = handle._internalInstanceHandle;
     if (stateNode != null) {
-      nativeFabricUIManager.sendAccessibilityEvent(stateNode.node, eventType);
+      fabricSendAccessibilityEvent(stateNode.node, eventType);
     }
   } else {
     legacySendAccessibilityEvent(handle._nativeTag, eventType);
diff --git a/packages/react-native-renderer/src/__tests__/ReactNativeError-test.internal.js b/packages/react-native-renderer/src/__tests__/ReactNativeError-test.internal.js
index 447ce2ac2ebbb..0b55cd79b3d64 100644
--- a/packages/react-native-renderer/src/__tests__/ReactNativeError-test.internal.js
+++ b/packages/react-native-renderer/src/__tests__/ReactNativeError-test.internal.js
@@ -28,6 +28,8 @@ describe('ReactNativeError', () => {
   beforeEach(() => {
     jest.resetModules();
 
+    require('react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager');
+
     React = require('react');
     ReactNative = require('react-native-renderer');
     createReactNativeComponentClass = require('react-native/Libraries/ReactPrivate/ReactNativePrivateInterface')
diff --git a/packages/react-native-renderer/src/__tests__/ReactNativeEvents-test.internal.js b/packages/react-native-renderer/src/__tests__/ReactNativeEvents-test.internal.js
index 2ebb2bcdc82cc..5e0524fbfc08d 100644
--- a/packages/react-native-renderer/src/__tests__/ReactNativeEvents-test.internal.js
+++ b/packages/react-native-renderer/src/__tests__/ReactNativeEvents-test.internal.js
@@ -63,6 +63,8 @@ const fakeRequireNativeComponent = (uiViewClassName, validAttributes) => {
 beforeEach(() => {
   jest.resetModules();
 
+  require('react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager');
+
   PropTypes = require('prop-types');
   RCTEventEmitter = require('react-native/Libraries/ReactPrivate/ReactNativePrivateInterface')
     .RCTEventEmitter;
diff --git a/packages/react-native-renderer/src/__tests__/ReactNativeMount-test.internal.js b/packages/react-native-renderer/src/__tests__/ReactNativeMount-test.internal.js
index 02482c2028b38..c16a74c475b5f 100644
--- a/packages/react-native-renderer/src/__tests__/ReactNativeMount-test.internal.js
+++ b/packages/react-native-renderer/src/__tests__/ReactNativeMount-test.internal.js
@@ -30,6 +30,8 @@ describe('ReactNative', () => {
   beforeEach(() => {
     jest.resetModules();
 
+    require('react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager');
+
     React = require('react');
     StrictMode = React.StrictMode;
     ReactNative = require('react-native-renderer');
diff --git a/packages/react-native-renderer/src/__tests__/createReactNativeComponentClass-test.internal.js b/packages/react-native-renderer/src/__tests__/createReactNativeComponentClass-test.internal.js
index d7a15a8c8dd62..0bef8a2dc4499 100644
--- a/packages/react-native-renderer/src/__tests__/createReactNativeComponentClass-test.internal.js
+++ b/packages/react-native-renderer/src/__tests__/createReactNativeComponentClass-test.internal.js
@@ -18,6 +18,8 @@ describe('createReactNativeComponentClass', () => {
   beforeEach(() => {
     jest.resetModules();
 
+    require('react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager');
+
     createReactNativeComponentClass = require('react-native/Libraries/ReactPrivate/ReactNativePrivateInterface')
       .ReactNativeViewConfigRegistry.register;
     React = require('react');