diff --git a/packages/react-interactions/accessibility/src/FocusList.js b/packages/react-interactions/accessibility/src/FocusList.js
index 2338436bd3d03..5082b8ac6f333 100644
--- a/packages/react-interactions/accessibility/src/FocusList.js
+++ b/packages/react-interactions/accessibility/src/FocusList.js
@@ -12,6 +12,7 @@ import type {KeyboardEvent} from 'react-interactions/events/keyboard';
 
 import React from 'react';
 import {useKeyboard} from 'react-interactions/events/keyboard';
+import {setElementCanTab} from 'react-interactions/accessibility/focus-control';
 
 type FocusItemProps = {
   children?: React.Node,
@@ -22,6 +23,7 @@ type FocusListProps = {|
   children: React.Node,
   portrait: boolean,
   wrap?: boolean,
+  tabScope?: ReactScope,
 |};
 
 const {useRef} = React;
@@ -41,7 +43,7 @@ function getPreviousListItem(
   const items = list.getChildren();
   if (items !== null) {
     const currentItemIndex = items.indexOf(currentItem);
-    const wrap = getListWrapProp(currentItem);
+    const wrap = getListProps(currentItem).wrap;
     if (currentItemIndex === 0 && wrap) {
       return items[items.length - 1] || null;
     } else if (currentItemIndex > 0) {
@@ -58,7 +60,7 @@ function getNextListItem(
   const items = list.getChildren();
   if (items !== null) {
     const currentItemIndex = items.indexOf(currentItem);
-    const wrap = getListWrapProp(currentItem);
+    const wrap = getListProps(currentItem).wrap;
     const end = currentItemIndex === items.length - 1;
     if (end && wrap) {
       return items[0] || null;
@@ -69,22 +71,38 @@ function getNextListItem(
   return null;
 }
 
-function getListWrapProp(currentItem: ReactScopeMethods): boolean {
-  const list = currentItem.getParent();
+function getListProps(currentCell: ReactScopeMethods): Object {
+  const list = currentCell.getParent();
   if (list !== null) {
     const listProps = list.getProps();
-    return (listProps.type === 'list' && listProps.wrap) || false;
+    if (listProps && listProps.type === 'list') {
+      return listProps;
+    }
   }
-  return false;
+  return {};
 }
 
 export function createFocusList(scope: ReactScope): Array<React.Component> {
   const TableScope = React.unstable_createScope(scope.fn);
 
-  function List({children, portrait, wrap}): FocusListProps {
+  function List({
+    children,
+    portrait,
+    wrap,
+    tabScope: TabScope,
+  }): FocusListProps {
+    const tabScopeRef = useRef(null);
     return (
-      <TableScope type="list" portrait={portrait} wrap={wrap}>
-        {children}
+      <TableScope
+        type="list"
+        portrait={portrait}
+        wrap={wrap}
+        tabScopeRef={tabScopeRef}>
+        {TabScope ? (
+          <TabScope ref={tabScopeRef}>{children}</TabScope>
+        ) : (
+          children
+        )}
       </TableScope>
     );
   }
@@ -100,6 +118,24 @@ export function createFocusList(scope: ReactScope): Array<React.Component> {
           if (list !== null && listProps.type === 'list') {
             const portrait = listProps.portrait;
             switch (event.key) {
+              case 'Tab': {
+                const tabScope = getListProps(currentItem).tabScopeRef.current;
+                if (tabScope) {
+                  const activeNode = document.activeElement;
+                  const nodes = tabScope.getScopedNodes();
+                  for (let i = 0; i < nodes.length; i++) {
+                    const node = nodes[i];
+                    if (node !== activeNode) {
+                      setElementCanTab(node, false);
+                    } else {
+                      setElementCanTab(node, true);
+                    }
+                  }
+                  return;
+                }
+                event.continuePropagation();
+                return;
+              }
               case 'ArrowUp': {
                 if (portrait) {
                   const previousListItem = getPreviousListItem(
diff --git a/packages/react-interactions/accessibility/src/FocusManager.js b/packages/react-interactions/accessibility/src/FocusManager.js
index 34d4b9e44cfcc..12a37297b9a01 100644
--- a/packages/react-interactions/accessibility/src/FocusManager.js
+++ b/packages/react-interactions/accessibility/src/FocusManager.js
@@ -64,6 +64,7 @@ const FocusManager = React.forwardRef(
       onBlurWithin: function(event) {
         if (!containFocus) {
           event.continuePropagation();
+          return;
         }
         const lastNode = event.target;
         if (lastNode) {
diff --git a/packages/react-interactions/accessibility/src/FocusTable.js b/packages/react-interactions/accessibility/src/FocusTable.js
index d658de2aa545b..6e1ae6a75b6a2 100644
--- a/packages/react-interactions/accessibility/src/FocusTable.js
+++ b/packages/react-interactions/accessibility/src/FocusTable.js
@@ -31,6 +31,7 @@ type FocusTableProps = {|
     focusTableByID: (id: string) => void,
   ) => void,
   wrap?: boolean,
+  tabScope?: ReactScope,
 |};
 
 const {useRef} = React;
diff --git a/packages/react-interactions/accessibility/src/__tests__/FocusList-test.internal.js b/packages/react-interactions/accessibility/src/__tests__/FocusList-test.internal.js
index e880d06c0437c..6d164eb6bdee0 100644
--- a/packages/react-interactions/accessibility/src/__tests__/FocusList-test.internal.js
+++ b/packages/react-interactions/accessibility/src/__tests__/FocusList-test.internal.js
@@ -7,7 +7,10 @@
  * @flow
  */
 
-import {createEventTarget} from 'react-interactions/events/src/dom/testing-library';
+import {
+  createEventTarget,
+  emulateBrowserTab,
+} from 'react-interactions/events/src/dom/testing-library';
 
 let React;
 let ReactFeatureFlags;
@@ -156,5 +159,74 @@ describe('FocusList', () => {
       });
       expect(document.activeElement.textContent).toBe('Item 3');
     });
+
+    it('handles keyboard arrow operations mixed with tabbing', () => {
+      const [FocusList, FocusItem] = createFocusList(TabbableScope);
+      const beforeRef = React.createRef();
+      const afterRef = React.createRef();
+
+      function Test() {
+        return (
+          <>
+            <input placeholder="Before" ref={beforeRef} />
+            <FocusList tabScope={TabbableScope} portrait={true}>
+              <ul>
+                <FocusItem>
+                  <li>
+                    <input placeholder="A" />
+                  </li>
+                </FocusItem>
+                <FocusItem>
+                  <li>
+                    <input placeholder="B" />
+                  </li>
+                </FocusItem>
+                <FocusItem>
+                  <li>
+                    <input placeholder="C" />
+                  </li>
+                </FocusItem>
+                <FocusItem>
+                  <li>
+                    <input placeholder="D" />
+                  </li>
+                </FocusItem>
+                <FocusItem>
+                  <li>
+                    <input placeholder="E" />
+                  </li>
+                </FocusItem>
+                <FocusItem>
+                  <li>
+                    <input placeholder="F" />
+                  </li>
+                </FocusItem>
+              </ul>
+            </FocusList>
+            <input placeholder="After" ref={afterRef} />
+          </>
+        );
+      }
+
+      ReactDOM.render(<Test />, container);
+      beforeRef.current.focus();
+
+      expect(document.activeElement.placeholder).toBe('Before');
+      emulateBrowserTab();
+      expect(document.activeElement.placeholder).toBe('A');
+      emulateBrowserTab();
+      expect(document.activeElement.placeholder).toBe('After');
+      emulateBrowserTab(true);
+      expect(document.activeElement.placeholder).toBe('A');
+      const a = createEventTarget(document.activeElement);
+      a.keydown({
+        key: 'ArrowDown',
+      });
+      expect(document.activeElement.placeholder).toBe('B');
+      emulateBrowserTab();
+      expect(document.activeElement.placeholder).toBe('After');
+      emulateBrowserTab(true);
+      expect(document.activeElement.placeholder).toBe('B');
+    });
   });
 });
diff --git a/packages/react-interactions/accessibility/src/__tests__/FocusTable-test.internal.js b/packages/react-interactions/accessibility/src/__tests__/FocusTable-test.internal.js
index ce33fa1fe6482..eea6216713ae8 100644
--- a/packages/react-interactions/accessibility/src/__tests__/FocusTable-test.internal.js
+++ b/packages/react-interactions/accessibility/src/__tests__/FocusTable-test.internal.js
@@ -7,7 +7,10 @@
  * @flow
  */
 
-import {createEventTarget} from 'react-interactions/events/src/dom/testing-library';
+import {
+  createEventTarget,
+  emulateBrowserTab,
+} from 'react-interactions/events/src/dom/testing-library';
 
 let React;
 let ReactFeatureFlags;
@@ -29,33 +32,6 @@ describe('FocusTable', () => {
     let ReactDOM;
     let container;
 
-    function emulateBrowserTab(backwards) {
-      const activeElement = document.activeElement;
-      const focusedElem = createEventTarget(activeElement);
-      let defaultPrevented = false;
-      focusedElem.keydown({
-        key: 'Tab',
-        shiftKey: backwards,
-        preventDefault() {
-          defaultPrevented = true;
-        },
-      });
-      if (!defaultPrevented) {
-        // This is not a full spec compliant version, but should be suffice for this test
-        const focusableElems = Array.from(
-          document.querySelectorAll(
-            'input, button, select, textarea, a[href], [tabindex], [contenteditable], iframe, object, embed',
-          ),
-        ).filter(
-          elem => elem.tabIndex > -1 && !elem.disabled && !elem.contentEditable,
-        );
-        const idx = focusableElems.indexOf(activeElement);
-        if (idx !== -1) {
-          focusableElems[backwards ? idx - 1 : idx + 1].focus();
-        }
-      }
-    }
-
     beforeEach(() => {
       ReactDOM = require('react-dom');
       container = document.createElement('div');
diff --git a/packages/react-interactions/events/src/dom/testing-library/index.js b/packages/react-interactions/events/src/dom/testing-library/index.js
index d46f96a5058ce..acc92235395ca 100644
--- a/packages/react-interactions/events/src/dom/testing-library/index.js
+++ b/packages/react-interactions/events/src/dom/testing-library/index.js
@@ -158,6 +158,33 @@ function testWithPointerType(message, testFn) {
   });
 }
 
+function emulateBrowserTab(backwards) {
+  const activeElement = document.activeElement;
+  const focusedElem = createEventTarget(activeElement);
+  let defaultPrevented = false;
+  focusedElem.keydown({
+    key: 'Tab',
+    shiftKey: backwards,
+    preventDefault() {
+      defaultPrevented = true;
+    },
+  });
+  if (!defaultPrevented) {
+    // This is not a full spec compliant version, but should be suffice for this test
+    const focusableElems = Array.from(
+      document.querySelectorAll(
+        'input, button, select, textarea, a[href], [tabindex], [contenteditable], iframe, object, embed',
+      ),
+    ).filter(
+      elem => elem.tabIndex > -1 && !elem.disabled && !elem.contentEditable,
+    );
+    const idx = focusableElems.indexOf(activeElement);
+    if (idx !== -1) {
+      focusableElems[backwards ? idx - 1 : idx + 1].focus();
+    }
+  }
+}
+
 export {
   buttonsType,
   createEventTarget,
@@ -166,4 +193,5 @@ export {
   hasPointerEvent,
   setPointerEvent,
   testWithPointerType,
+  emulateBrowserTab,
 };
diff --git a/scripts/rollup/bundles.js b/scripts/rollup/bundles.js
index 20069c4841797..34f146d8a2a54 100644
--- a/scripts/rollup/bundles.js
+++ b/scripts/rollup/bundles.js
@@ -718,6 +718,7 @@ const bundles = [
       'react',
       'react-interactions/events/keyboard',
       'react-interactions/accessibility/tabbable-scope',
+      'react-interactions/accessibility/focus-control',
     ],
   },
 ];