diff --git a/src-docs/src/components/scroll_to_hash.tsx b/src-docs/src/components/scroll_to_hash.tsx
index 23a6bb59b27..678a8494d77 100644
--- a/src-docs/src/components/scroll_to_hash.tsx
+++ b/src-docs/src/components/scroll_to_hash.tsx
@@ -1,5 +1,6 @@
 import { useEffect, useState, FunctionComponent } from 'react';
 import { useLocation } from 'react-router-dom';
+import { isTabbable } from 'tabbable';
 
 const ScrollToHash: FunctionComponent = () => {
   const location = useLocation();
@@ -18,11 +19,23 @@ const ScrollToHash: FunctionComponent = () => {
     const element = document.getElementById(hash);
     const headerOffset = 48;
     if (element) {
+      // Focus element for keyboard and screen reader users
+      if (!isTabbable(element)) {
+        element.tabIndex = -1;
+        element.addEventListener(
+          'blur',
+          () => element.removeAttribute('tabindex'),
+          { once: true }
+        );
+        element.focus();
+      }
+      // Scroll to element
       window.scrollTo({
         top: element.offsetTop - headerOffset,
         behavior: 'smooth',
       });
     } else {
+      // Scroll back to top of page
       window.scrollTo({
         behavior: 'auto',
         top: 0,
diff --git a/src-docs/src/views/accessibility/accessibility_example.js b/src-docs/src/views/accessibility/accessibility_example.js
index fde94031ff8..202d6805b16 100644
--- a/src-docs/src/views/accessibility/accessibility_example.js
+++ b/src-docs/src/views/accessibility/accessibility_example.js
@@ -13,12 +13,14 @@ import {
 } from '../../../../src';
 
 import ScreenReaderLive from './screen_reader_live';
+import ScreenReaderLiveFocus from './screen_reader_live_focus';
 import ScreenReaderOnly from './screen_reader';
 import ScreenReaderFocus from './screen_reader_focus';
 import SkipLink from './skip_link';
 import StylesHelpers from './styles_helpers';
 
 const screenReaderLiveSource = require('!!raw-loader!./screen_reader_live');
+const screenReaderLiveFocusSource = require('!!raw-loader!./screen_reader_live_focus');
 const screenReaderOnlySource = require('!!raw-loader!./screen_reader');
 const screenReaderFocusSource = require('!!raw-loader!./screen_reader_focus');
 
@@ -154,8 +156,50 @@ export const AccessibilityExample = {
       props: {
         EuiScreenReaderLive,
       },
+      snippet: `<EuiScreenReaderLive>
+  <!-- visually hidden announced content -->
+</EuiScreenReaderLive>`,
       demo: <ScreenReaderLive />,
     },
+    {
+      text: (
+        <>
+          <h3>Auto-focusing the live region on text change</h3>
+          <p>
+            The <EuiCode>focusRegionOnTextChange</EuiCode> prop will
+            automatically focus the <EuiCode>EuiScreenReaderLive</EuiCode>{' '}
+            region (causing screen readers to read out the text content)
+            whenever <EuiCode>children</EuiCode> changes.
+          </p>
+          <p>
+            This is primarily useful for announcing navigation or page changes,
+            when programmatically resetting focus location back to a certain
+            part of the page (where the <EuiCode>EuiScreenReaderLive</EuiCode>{' '}
+            is placed) is desired.
+          </p>
+          <p>
+            <em>
+              Using a screen reader, click the following navigation links and
+              notice that when the new page is announced, focus is also set to
+              the top of the body content.
+            </em>
+          </p>
+        </>
+      ),
+      props: {
+        EuiScreenReaderLive,
+      },
+      snippet: `<EuiScreenReaderLive focusRegionOnTextChange>
+  <!-- visually hidden content, focused and announced on text change -->
+</EuiScreenReaderLive>`,
+      demo: <ScreenReaderLiveFocus />,
+      source: [
+        {
+          type: GuideSectionTypes.TSX,
+          code: screenReaderLiveFocusSource,
+        },
+      ],
+    },
     {
       title: 'Skip link',
       source: [
diff --git a/src-docs/src/views/accessibility/screen_reader_live_focus.tsx b/src-docs/src/views/accessibility/screen_reader_live_focus.tsx
new file mode 100644
index 00000000000..d06df404f97
--- /dev/null
+++ b/src-docs/src/views/accessibility/screen_reader_live_focus.tsx
@@ -0,0 +1,63 @@
+import React, { useState } from 'react';
+
+import {
+  EuiScreenReaderLive,
+  EuiPageTemplate,
+  EuiSideNav,
+  EuiButton,
+} from '../../../../src/components';
+import { htmlIdGenerator } from '../../../../src/services';
+
+export default () => {
+  const idGenerator = htmlIdGenerator('focusRegionOnTextChange');
+
+  const [pageTitle, setPageTitle] = useState('Home');
+
+  const sideNav = [
+    {
+      name: 'Example side nav',
+      id: idGenerator(),
+      items: [
+        {
+          name: 'Home',
+          id: idGenerator(),
+          onClick: () => setPageTitle('Home'),
+        },
+        {
+          name: 'About',
+          id: idGenerator(),
+          onClick: () => setPageTitle('About'),
+        },
+        {
+          name: 'Docs',
+          id: idGenerator(),
+          onClick: () => setPageTitle('Docs'),
+        },
+        {
+          name: 'Contact',
+          id: idGenerator(),
+          onClick: () => setPageTitle('Contact'),
+        },
+      ],
+    },
+  ];
+
+  return (
+    <>
+      <EuiPageTemplate
+        pageSideBar={<EuiSideNav items={sideNav} isOpenOnMobile />}
+        pageHeader={{
+          iconType: 'logoElastic',
+          pageTitle: pageTitle,
+        }}
+      >
+        <EuiScreenReaderLive focusRegionOnTextChange>
+          {pageTitle}
+        </EuiScreenReaderLive>
+        <EuiButton>
+          Clicking a nav link and then pressing tab should focus this button
+        </EuiButton>
+      </EuiPageTemplate>
+    </>
+  );
+};
diff --git a/src-docs/src/views/app_view.js b/src-docs/src/views/app_view.js
index 132653906b8..21e61b29828 100644
--- a/src-docs/src/views/app_view.js
+++ b/src-docs/src/views/app_view.js
@@ -10,6 +10,7 @@ import {
   EuiPage,
   EuiPageBody,
   EuiSkipLink,
+  EuiScreenReaderLive,
 } from '../../../src/components';
 
 import { keys } from '../../../src/services';
@@ -69,7 +70,11 @@ export const AppView = ({ children, currentRoute }) => {
 
   return (
     <LinkWrapper>
+      <EuiScreenReaderLive focusRegionOnTextChange>
+        {`${currentRoute.name} - Elastic UI Framework`}
+      </EuiScreenReaderLive>
       <EuiSkipLink
+        color="ghost"
         destinationId="start-of-content"
         position="fixed"
         overrideLinkBehavior
diff --git a/src/components/accessibility/screen_reader_live/__snapshots__/screen_reader_live.test.tsx.snap b/src/components/accessibility/screen_reader_live/__snapshots__/screen_reader_live.test.tsx.snap
index f69ffba8254..4ee08078ce1 100644
--- a/src/components/accessibility/screen_reader_live/__snapshots__/screen_reader_live.test.tsx.snap
+++ b/src/components/accessibility/screen_reader_live/__snapshots__/screen_reader_live.test.tsx.snap
@@ -6,6 +6,7 @@ exports[`EuiScreenReaderLive with a static configuration accepts \`aria-live\` 1
 >
   <div
     aria-atomic="true"
+    aria-hidden="true"
     aria-live="assertive"
     role="status"
   />
@@ -21,12 +22,36 @@ exports[`EuiScreenReaderLive with a static configuration accepts \`aria-live\` 1
 </div>
 `;
 
+exports[`EuiScreenReaderLive with a static configuration accepts \`focusRegionOnTextChange\` 1`] = `
+<div
+  class="emotion-euiScreenReaderOnly"
+  tabindex="-1"
+>
+  <div
+    aria-atomic="true"
+    aria-hidden="true"
+    aria-live="off"
+    role="status"
+  />
+  <div
+    aria-atomic="true"
+    aria-live="off"
+    role="status"
+  >
+    <p>
+      This paragraph is not visible to sighted users but will be read by screenreaders.
+    </p>
+  </div>
+</div>
+`;
+
 exports[`EuiScreenReaderLive with a static configuration accepts \`role\` 1`] = `
 <div
   class="emotion-euiScreenReaderOnly"
 >
   <div
     aria-atomic="true"
+    aria-hidden="true"
     aria-live="polite"
     role="log"
   />
@@ -48,6 +73,7 @@ exports[`EuiScreenReaderLive with a static configuration does not render screen
 >
   <div
     aria-atomic="true"
+    aria-hidden="true"
     aria-live="polite"
     role="status"
   />
@@ -65,6 +91,7 @@ exports[`EuiScreenReaderLive with a static configuration renders screen reader c
 >
   <div
     aria-atomic="true"
+    aria-hidden="true"
     aria-live="polite"
     role="status"
   />
@@ -92,6 +119,7 @@ exports[`EuiScreenReaderLive with dynamic properties alternates rendering screen
   >
     <div
       aria-atomic="true"
+      aria-hidden="true"
       aria-live="polite"
       role="status"
     />
@@ -120,6 +148,7 @@ exports[`EuiScreenReaderLive with dynamic properties initially renders screen re
   >
     <div
       aria-atomic="true"
+      aria-hidden="true"
       aria-live="polite"
       role="status"
     />
diff --git a/src/components/accessibility/screen_reader_live/screen_reader_live.test.tsx b/src/components/accessibility/screen_reader_live/screen_reader_live.test.tsx
index 4043bfcbba1..521457ed849 100644
--- a/src/components/accessibility/screen_reader_live/screen_reader_live.test.tsx
+++ b/src/components/accessibility/screen_reader_live/screen_reader_live.test.tsx
@@ -13,15 +13,15 @@ import { findTestSubject } from '../../../test';
 
 import { EuiScreenReaderLive } from './screen_reader_live';
 
+const content = (
+  <p>
+    This paragraph is not visible to sighted users but will be read by
+    screenreaders.
+  </p>
+);
+
 describe('EuiScreenReaderLive', () => {
   describe('with a static configuration', () => {
-    const content = (
-      <p>
-        This paragraph is not visible to sighted users but will be read by
-        screenreaders.
-      </p>
-    );
-
     it('renders screen reader content when active', () => {
       const component = render(
         <EuiScreenReaderLive isActive={true}>{content}</EuiScreenReaderLive>
@@ -55,6 +55,16 @@ describe('EuiScreenReaderLive', () => {
 
       expect(component).toMatchSnapshot();
     });
+
+    it('accepts `focusRegionOnTextChange`', () => {
+      const component = render(
+        <EuiScreenReaderLive focusRegionOnTextChange>
+          {content}
+        </EuiScreenReaderLive>
+      );
+
+      expect(component).toMatchSnapshot();
+    });
   });
 
   describe('with dynamic properties', () => {
@@ -90,4 +100,18 @@ describe('EuiScreenReaderLive', () => {
       expect(component.render()).toMatchSnapshot();
     });
   });
+
+  describe('with focus behavior', () => {
+    it('sets focus correctly', () => {
+      const component = mount(
+        <EuiScreenReaderLive focusRegionOnTextChange={true}>
+          {content}
+        </EuiScreenReaderLive>
+      );
+
+      const focusableDiv = component.find('div').at(0);
+
+      expect(focusableDiv.is(':focus')).toBe(true);
+    });
+  });
 });
diff --git a/src/components/accessibility/screen_reader_live/screen_reader_live.tsx b/src/components/accessibility/screen_reader_live/screen_reader_live.tsx
index 88d4a256497..40c84dbb5e4 100644
--- a/src/components/accessibility/screen_reader_live/screen_reader_live.tsx
+++ b/src/components/accessibility/screen_reader_live/screen_reader_live.tsx
@@ -12,6 +12,7 @@ import React, {
   FunctionComponent,
   ReactNode,
   useEffect,
+  useRef,
   useState,
 } from 'react';
 
@@ -36,6 +37,13 @@ export interface EuiScreenReaderLiveProps {
    * `aria-live` attribute for both live regions
    */
   'aria-live'?: AriaAttributes['aria-live'];
+  /**
+   * On `children`/text change, the region will auto-focus itself, causing screen readers
+   * to automatically read out the text content. This prop should primarily be used for
+   * navigation or page changes, where programmatically resetting focus location back to
+   * a certain part of the page is desired.
+   */
+  focusRegionOnTextChange?: boolean;
 }
 
 export const EuiScreenReaderLive: FunctionComponent<EuiScreenReaderLiveProps> = ({
@@ -43,13 +51,21 @@ export const EuiScreenReaderLive: FunctionComponent<EuiScreenReaderLiveProps> =
   isActive = true,
   role = 'status',
   'aria-live': ariaLive = 'polite',
+  focusRegionOnTextChange = false,
 }) => {
   const [toggle, setToggle] = useState(false);
+  const focusRef = useRef<HTMLDivElement>(null);
 
   useEffect(() => {
     setToggle((toggle) => !toggle);
   }, [children]);
 
+  useEffect(() => {
+    if (focusRef.current !== null && focusRegionOnTextChange) {
+      focusRef.current.focus();
+    }
+  }, [toggle, focusRegionOnTextChange]);
+
   return (
     /**
      * Intentionally uses two persistent live regions with oscillating content updates.
@@ -62,11 +78,23 @@ export const EuiScreenReaderLive: FunctionComponent<EuiScreenReaderLiveProps> =
      * for more examples of the double region approach.
      */
     <EuiScreenReaderOnly>
-      <div>
-        <div role={role} aria-atomic="true" aria-live={ariaLive}>
+      <div ref={focusRef} tabIndex={focusRegionOnTextChange ? -1 : undefined}>
+        <div
+          role={role}
+          aria-atomic="true"
+          // Setting `aria-hidden` and setting `aria-live` to "off" prevents
+          // double announcements from VO when `focusRegionOnTextChange` is true
+          aria-hidden={toggle ? undefined : 'true'}
+          aria-live={focusRegionOnTextChange ? 'off' : ariaLive}
+        >
           {isActive && toggle ? children : ''}
         </div>
-        <div role={role} aria-atomic="true" aria-live={ariaLive}>
+        <div
+          role={role}
+          aria-atomic="true"
+          aria-hidden={!toggle ? undefined : 'true'}
+          aria-live={focusRegionOnTextChange ? 'off' : ariaLive}
+        >
           {isActive && !toggle ? children : ''}
         </div>
       </div>
diff --git a/src/components/selectable/__snapshots__/selectable.test.tsx.snap b/src/components/selectable/__snapshots__/selectable.test.tsx.snap
index 1ecede0d768..1b971ea735b 100644
--- a/src/components/selectable/__snapshots__/selectable.test.tsx.snap
+++ b/src/components/selectable/__snapshots__/selectable.test.tsx.snap
@@ -340,6 +340,7 @@ exports[`EuiSelectable search value supports inheriting initialSearchValue from
   >
     <div
       aria-atomic="true"
+      aria-hidden="true"
       aria-live="polite"
       role="status"
     />
diff --git a/upcoming_changelogs/5995.md b/upcoming_changelogs/5995.md
new file mode 100644
index 00000000000..8fb20dc8683
--- /dev/null
+++ b/upcoming_changelogs/5995.md
@@ -0,0 +1 @@
+- Added `focusRegionOnTextChange` prop to `EuiScreenReaderLive`