diff --git a/eng/native/functions.cmake b/eng/native/functions.cmake
index 420b7d1a88f7c..df293a2cc8310 100644
--- a/eng/native/functions.cmake
+++ b/eng/native/functions.cmake
@@ -143,8 +143,38 @@ function(preprocess_file inputFilename outputFilename)
                               PROPERTIES GENERATED TRUE)
 endfunction()
 
-# preprocess_compile_asm(TARGET target ASM_FILES file1 [file2 ...] OUTPUT_OBJECTS [variableName])
-function(preprocess_compile_asm)
+# preprocess_files(PreprocessedFilesList [fileToPreprocess1 [fileToPreprocess2 ...]])
+function(preprocess_files PreprocessedFilesList)
+  set(FilesToPreprocess ${ARGN})
+  foreach(ASM_FILE IN LISTS FilesToPreprocess)
+    # Inserts a custom command in CMake build to preprocess each asm source file
+    get_filename_component(name ${ASM_FILE} NAME_WE)
+    file(TO_CMAKE_PATH "${CMAKE_CURRENT_BINARY_DIR}/${name}.asm" ASM_PREPROCESSED_FILE)
+    preprocess_file(${ASM_FILE} ${ASM_PREPROCESSED_FILE})
+    list(APPEND PreprocessedFiles ${ASM_PREPROCESSED_FILE})
+  endforeach()
+  set(${PreprocessedFilesList} ${PreprocessedFiles} PARENT_SCOPE)
+endfunction()
+
+function(set_exports_linker_option exports_filename)
+    if(LD_GNU OR LD_SOLARIS)
+        # Add linker exports file option
+        if(LD_SOLARIS)
+            set(EXPORTS_LINKER_OPTION -Wl,-M,${exports_filename} PARENT_SCOPE)
+        else()
+            set(EXPORTS_LINKER_OPTION -Wl,--version-script=${exports_filename} PARENT_SCOPE)
+        endif()
+    elseif(LD_OSX)
+        # Add linker exports file option
+        set(EXPORTS_LINKER_OPTION -Wl,-exported_symbols_list,${exports_filename} PARENT_SCOPE)
+    endif()
+endfunction()
+
+# compile_asm(TARGET target ASM_FILES file1 [file2 ...] OUTPUT_OBJECTS [variableName])
+# CMake does not support the ARM or ARM64 assemblers on Windows when using the
+# MSBuild generator. When the MSBuild generator is in use, we manually compile the assembly files
+# using this function.
+function(compile_asm)
   set(options "")
   set(oneValueArgs TARGET OUTPUT_OBJECTS)
   set(multiValueArgs ASM_FILES)
@@ -155,10 +185,7 @@ function(preprocess_compile_asm)
   set (ASSEMBLED_OBJECTS "")
 
   foreach(ASM_FILE ${COMPILE_ASM_ASM_FILES})
-    # Inserts a custom command in CMake build to preprocess each asm source file
     get_filename_component(name ${ASM_FILE} NAME_WE)
-    file(TO_CMAKE_PATH "${CMAKE_CURRENT_BINARY_DIR}/${name}.asm" ASM_PREPROCESSED_FILE)
-    preprocess_file(${ASM_FILE} ${ASM_PREPROCESSED_FILE})
 
     # Produce object file where CMake would store .obj files for an OBJECT library.
     # ex: artifacts\obj\coreclr\Windows_NT.arm64.Debug\src\vm\wks\cee_wks.dir\Debug\AsmHelpers.obj
@@ -166,9 +193,9 @@ function(preprocess_compile_asm)
 
     # Need to compile asm file using custom command as include directories are not provided to asm compiler
     add_custom_command(OUTPUT ${OBJ_FILE}
-                        COMMAND "${CMAKE_ASM_MASM_COMPILER}" -g ${ASM_INCLUDE_DIRECTORIES} -o ${OBJ_FILE} ${ASM_PREPROCESSED_FILE}
-                        DEPENDS ${ASM_PREPROCESSED_FILE}
-                        COMMENT "Assembling ${ASM_PREPROCESSED_FILE} ---> \"${CMAKE_ASM_MASM_COMPILER}\" -g ${ASM_INCLUDE_DIRECTORIES} -o ${OBJ_FILE} ${ASM_PREPROCESSED_FILE}")
+                        COMMAND "${CMAKE_ASM_COMPILER}" -g ${ASM_INCLUDE_DIRECTORIES} -o ${OBJ_FILE} ${ASM_FILE}
+                        DEPENDS ${ASM_FILE}
+                        COMMENT "Assembling ${ASM_FILE} ---> \"${CMAKE_ASM_COMPILER}\" -g ${ASM_INCLUDE_DIRECTORIES} -o ${OBJ_FILE} ${ASM_FILE}")
 
     # mark obj as source that does not require compile
     set_source_files_properties(${OBJ_FILE} PROPERTIES EXTERNAL_OBJECT TRUE)
diff --git a/eng/pipelines/common/templates/runtimes/build-test-job.yml b/eng/pipelines/common/templates/runtimes/build-test-job.yml
index c4eabe0eaa429..bd4e2a7af88e4 100644
--- a/eng/pipelines/common/templates/runtimes/build-test-job.yml
+++ b/eng/pipelines/common/templates/runtimes/build-test-job.yml
@@ -89,10 +89,6 @@ jobs:
     - ${{ if eq(parameters.osGroup, 'OSX') }}:
       - script: $(Build.SourcesDirectory)/eng/install-native-dependencies.sh $(osGroup)
         displayName: Install native dependencies
-    - ${{ if eq(parameters.osGroup, 'Windows_NT') }}:
-      # Necessary to install correct cmake version
-      - script: $(Build.SourcesDirectory)\eng\common\init-tools-native.cmd -InstallDirectory $(Build.SourcesDirectory)\native-tools -Force
-        displayName: Install native dependencies
 
 
     # Optionally download live-built libraries
@@ -113,17 +109,17 @@ jobs:
         artifactName: '$(coreClrProductArtifactName)'
         displayName: 'CoreCLR product build'
 
-    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}: 
+    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}:
       - script: |
           du -sh $(Build.SourcesDirectory)/*
           df -h
         displayName: Disk Usage before Build
-    
+
     # Build managed test components
     - script: $(Build.SourcesDirectory)/src/coreclr/build-test$(scriptExt) allTargets skipstressdependencies skipnative skipgeneratelayout skiptestwrappers $(buildConfig) $(archType) $(crossArg) $(priorityArg) ci $(librariesOverrideArg)
       displayName: Build managed test components
 
-    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}: 
+    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}:
       - script: |
           du -sh $(Build.SourcesDirectory)/*
           df -h
diff --git a/eng/pipelines/coreclr/templates/build-job.yml b/eng/pipelines/coreclr/templates/build-job.yml
index 91a5cb0624751..a58d4bab04afe 100644
--- a/eng/pipelines/coreclr/templates/build-job.yml
+++ b/eng/pipelines/coreclr/templates/build-job.yml
@@ -121,10 +121,6 @@ jobs:
     - ${{ if eq(parameters.osGroup, 'OSX') }}:
       - script: $(Build.SourcesDirectory)/eng/install-native-dependencies.sh $(osGroup)
         displayName: Install native dependencies
-    - ${{ if eq(parameters.osGroup, 'Windows_NT') }}:
-      # Necessary to install python
-      - script: $(Build.SourcesDirectory)\eng\common\init-tools-native.cmd -InstallDirectory $(Build.SourcesDirectory)\native-tools -Force
-        displayName: Install native dependencies
 
     # Install internal tools on official builds
     # Since our internal tools are behind an authenticated feed,
@@ -173,7 +169,7 @@ jobs:
 
         - template: /eng/pipelines/common/macos-sign-with-entitlements.yml
           parameters:
-            filesToSign: 
+            filesToSign:
             - name: createdump
               path: $(buildProductRootFolderPath)
               entitlementsFile: $(Build.SourcesDirectory)/eng/pipelines/common/createdump-entitlements.plist
diff --git a/eng/pipelines/mono/templates/build-job.yml b/eng/pipelines/mono/templates/build-job.yml
index e46ca5ee005f2..36cc1c6b36334 100644
--- a/eng/pipelines/mono/templates/build-job.yml
+++ b/eng/pipelines/mono/templates/build-job.yml
@@ -89,12 +89,8 @@ jobs:
     - ${{ if in(parameters.osGroup, 'OSX', 'iOS', 'tvOS') }}:
       - script: $(Build.SourcesDirectory)/eng/install-native-dependencies.sh $(osGroup)
         displayName: Install native dependencies
-    - ${{ if eq(parameters.osGroup, 'Windows_NT') }}:
-      # Necessary to install python
-      - script: $(Build.SourcesDirectory)\eng\common\init-tools-native.cmd -InstallDirectory $(Build.SourcesDirectory)\native-tools -Force
-        displayName: Install native dependencies
 
-    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}: 
+    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}:
       - script: |
           du -sh $(Build.SourcesDirectory)/*
           df -h
@@ -108,7 +104,7 @@ jobs:
       - script: build$(scriptExt) -subset mono -c $(buildConfig) -arch $(archType) $(osOverride) -ci $(officialBuildIdArg) $(llvmParameter)
         displayName: Build product
 
-    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}: 
+    - ${{ if in(parameters.osGroup, 'OSX', 'iOS','tvOS') }}:
       - script: |
           du -sh $(Build.SourcesDirectory)/*
           df -h
diff --git a/global.json b/global.json
index 7822077ad2c3b..ea7f876afea52 100644
--- a/global.json
+++ b/global.json
@@ -7,10 +7,6 @@
   "tools": {
     "dotnet": "5.0.401"
   },
-  "native-tools": {
-    "cmake": "3.14.5",
-    "python3": "3.7.1"
-  },
   "msbuild-sdks": {
     "Microsoft.DotNet.Build.Tasks.TargetFramework.Sdk": "5.0.0-beta.21565.1",
     "Microsoft.DotNet.Arcade.Sdk": "5.0.0-beta.21565.1",
diff --git a/src/coreclr/src/debug/di/CMakeLists.txt b/src/coreclr/src/debug/di/CMakeLists.txt
index 6cfedda1d8990..1637cd14f6120 100644
--- a/src/coreclr/src/debug/di/CMakeLists.txt
+++ b/src/coreclr/src/debug/di/CMakeLists.txt
@@ -59,7 +59,11 @@ if(CLR_CMAKE_HOST_WIN32)
 
     if ((CLR_CMAKE_TARGET_ARCH_ARM OR CLR_CMAKE_TARGET_ARCH_ARM64) AND NOT DEFINED CLR_CROSS_COMPONENTS_BUILD)
         convert_to_absolute_path(CORDBDI_SOURCES_ASM_FILE ${CORDBDI_SOURCES_ASM_FILE})
-        preprocess_compile_asm(TARGET cordbdi ASM_FILES ${CORDBDI_SOURCES_ASM_FILE} OUTPUT_OBJECTS CORDBDI_SOURCES_ASM_FILE)
+        preprocess_files(CORDBDI_SOURCES_ASM_FILE ${CORDBDI_SOURCES_ASM_FILE})
+
+        if (CMAKE_GENERATOR MATCHES "Visual Studio")
+            compile_asm(TARGET cordbdi ASM_FILES ${CORDBDI_SOURCES_ASM_FILE} OUTPUT_OBJECTS CORDBDI_SOURCES_ASM_FILE)
+        endif()
     endif()
 elseif(CLR_CMAKE_HOST_UNIX)
 
diff --git a/src/coreclr/src/debug/ee/wks/CMakeLists.txt b/src/coreclr/src/debug/ee/wks/CMakeLists.txt
index 3dd5e3612dfc8..6d637da54063f 100644
--- a/src/coreclr/src/debug/ee/wks/CMakeLists.txt
+++ b/src/coreclr/src/debug/ee/wks/CMakeLists.txt
@@ -9,7 +9,11 @@ if (CLR_CMAKE_TARGET_WIN32)
 
   if(CLR_CMAKE_HOST_ARCH_ARM OR CLR_CMAKE_HOST_ARCH_ARM64)
 
-    preprocess_compile_asm(TARGET cordbee_wks_obj ASM_FILES ${ASM_FILE} OUTPUT_OBJECTS ASM_OBJECTS)
+    preprocess_files(ASM_FILE ${ASM_FILE})
+
+    if (CMAKE_GENERATOR MATCHES "Visual Studio")
+      compile_asm(TARGET cordbee_wks_obj ASM_FILES ${ASM_FILE} OUTPUT_OBJECTS ASM_OBJECTS)
+    endif()
 
     add_library_clr(cordbee_wks_obj OBJECT ${CORDBEE_SOURCES_WKS} ${ASM_FILE} ${ASM_OBJECTS})
 
diff --git a/src/coreclr/src/inc/crosscomp.h b/src/coreclr/src/inc/crosscomp.h
index 5b6e932fd24f6..6981fea2c9718 100644
--- a/src/coreclr/src/inc/crosscomp.h
+++ b/src/coreclr/src/inc/crosscomp.h
@@ -41,7 +41,9 @@
 #define ARM_MAX_BREAKPOINTS     8
 #define ARM_MAX_WATCHPOINTS     1
 
+#ifndef CONTEXT_UNWOUND_TO_CALL
 #define CONTEXT_UNWOUND_TO_CALL 0x20000000
+#endif
 
 typedef struct _NEON128 {
     ULONGLONG Low;
diff --git a/src/coreclr/src/vm/wks/CMakeLists.txt b/src/coreclr/src/vm/wks/CMakeLists.txt
index 7c3dd84bd3d03..1b34bf67b65d3 100644
--- a/src/coreclr/src/vm/wks/CMakeLists.txt
+++ b/src/coreclr/src/vm/wks/CMakeLists.txt
@@ -2,7 +2,11 @@
 if (CLR_CMAKE_TARGET_WIN32)
 
   if(CLR_CMAKE_HOST_ARCH_ARM OR CLR_CMAKE_HOST_ARCH_ARM64)
-    preprocess_compile_asm(TARGET cee_wks_core ASM_FILES ${VM_SOURCES_WKS_ARCH_ASM} OUTPUT_OBJECTS VM_WKS_ARCH_ASM_OBJECTS)
+    preprocess_files(VM_SOURCES_WKS_ARCH_ASM ${VM_SOURCES_WKS_ARCH_ASM})
+
+    if (CMAKE_GENERATOR MATCHES "Visual Studio")
+      compile_asm(TARGET cee_wks_core ASM_FILES ${VM_SOURCES_WKS_ARCH_ASM} OUTPUT_OBJECTS VM_WKS_ARCH_ASM_OBJECTS)
+    endif()
   endif()
 
 endif (CLR_CMAKE_TARGET_WIN32)
diff --git a/src/installer/corehost/cli/ijwhost/CMakeLists.txt b/src/installer/corehost/cli/ijwhost/CMakeLists.txt
index 4a56583af3a47..d790b01709f12 100644
--- a/src/installer/corehost/cli/ijwhost/CMakeLists.txt
+++ b/src/installer/corehost/cli/ijwhost/CMakeLists.txt
@@ -33,8 +33,10 @@ convert_to_absolute_path(SOURCES ${SOURCES})
 convert_to_absolute_path(ASM_HELPERS_SOURCES ${ASM_HELPERS_SOURCES})
 
 if (CLR_CMAKE_TARGET_WIN32 AND (CLR_CMAKE_TARGET_ARCH_ARM OR CLR_CMAKE_TARGET_ARCH_ARM64))
-    preprocess_compile_asm(TARGET ijwhost ASM_FILES ${ASM_HELPERS_SOURCES} OUTPUT_OBJECTS ASM_HELPERS_OBJECTS)
-    list(APPEND ASM_HELPERS_SOURCES ${ASM_HELPERS_OBJECTS})
+    preprocess_files(ASM_HELPERS_SOURCES ${ASM_HELPERS_SOURCES})
+    if (CMAKE_GENERATOR MATCHES "Visual Studio")
+        compile_asm(TARGET ijwhost ASM_FILES ${ASM_HELPERS_SOURCES} OUTPUT_OBJECTS ASM_HELPERS_SOURCES)
+    endif()
 endif ()
 
 if (CLR_CMAKE_TARGET_WIN32 AND CLR_CMAKE_TARGET_ARCH_I386)
diff --git a/src/mono/mono.proj b/src/mono/mono.proj
index a11853b47c527..b651d2ad769a3 100644
--- a/src/mono/mono.proj
+++ b/src/mono/mono.proj
@@ -810,7 +810,7 @@
       <MonoExec>$(LocalMonoDotnet)</MonoExec>
     </PropertyGroup>
     <ItemGroup>
-      <AssembliesToPrecompile 
+      <AssembliesToPrecompile
           Include="$(LocalMonoDotnetDir)\shared\Microsoft.NETCore.App\**\*.dll"
           Exclude="$(LocalMonoDotnetDir)\shared\Microsoft.NETCore.App\**\System.Runtime.WindowsRuntime.dll" />
     </ItemGroup>
@@ -848,7 +848,7 @@
     <Error Condition="'$(Destination)' == ''" Text="Destination should not be empty" />
     <Error Condition="@(_MonoRuntimeArtifacts->Count()) &lt; 2" Text="Mono artifacts were not found at $(BinDir)" />
     <Message Text="Copying Mono Runtime artifacts from '$(BinDir)' to '$(Destination)'.'" Importance="High" />
-    <Copy SourceFiles="@(_MonoRuntimeArtifacts)" 
+    <Copy SourceFiles="@(_MonoRuntimeArtifacts)"
           DestinationFolder="$(Destination)"
           OverwriteReadOnlyFiles="true" />
   </Target>
@@ -918,7 +918,7 @@
   <Target Name="RunLibrariesTest" DependsOnTargets="PatchLibrariesTesthost">
     <Error Condition="$(LibraryToTest) == ''" Text="LibraryToTest variable is not set" />
     <Error Condition="$(LibraryToTest.EndsWith('.Tests'))" Text="LibraryToTest should not end with .Tests, e.g. just 'System.Runtime'" />
-    <MSBuild Projects="$(RepoRoot)src\libraries\$(LibraryToTest)\tests\$(LibraryToTest).Tests.csproj" 
+    <MSBuild Projects="$(RepoRoot)src\libraries\$(LibraryToTest)\tests\$(LibraryToTest).Tests.csproj"
              Properties="Configuration=$(LibrariesTestConfig)" Targets="Test" />
   </Target>