diff --git a/superset/db_engine_specs/mssql.py b/superset/db_engine_specs/mssql.py
index 464f6cf2b9c8d..5b8ba457bafa3 100644
--- a/superset/db_engine_specs/mssql.py
+++ b/superset/db_engine_specs/mssql.py
@@ -14,6 +14,8 @@
 # KIND, either express or implied.  See the License for the
 # specific language governing permissions and limitations
 # under the License.
+from __future__ import annotations
+
 import logging
 import re
 from datetime import datetime
@@ -27,6 +29,7 @@
 from superset.constants import TimeGrain
 from superset.db_engine_specs.base import BaseEngineSpec, LimitMethod
 from superset.errors import SupersetErrorType
+from superset.models.sql_types.mssql_sql_types import GUID
 from superset.utils.core import GenericDataType
 
 logger = logging.getLogger(__name__)
@@ -87,6 +90,11 @@ class MssqlEngineSpec(BaseEngineSpec):
             SMALLDATETIME(),
             GenericDataType.TEMPORAL,
         ),
+        (
+            re.compile(r"^uniqueidentifier.*", re.IGNORECASE),
+            GUID(),
+            GenericDataType.STRING,
+        ),
     )
 
     custom_errors: dict[Pattern[str], tuple[str, SupersetErrorType, dict[str, Any]]] = {
diff --git a/superset/models/sql_types/mssql_sql_types.py b/superset/models/sql_types/mssql_sql_types.py
new file mode 100644
index 0000000000000..add40e31006ad
--- /dev/null
+++ b/superset/models/sql_types/mssql_sql_types.py
@@ -0,0 +1,61 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+
+# pylint: disable=abstract-method
+import uuid
+from typing import Any, Optional
+
+from sqlalchemy.engine.interfaces import Dialect
+from sqlalchemy.sql.sqltypes import CHAR
+from sqlalchemy.sql.visitors import Visitable
+from sqlalchemy.types import TypeDecorator
+
+# _compiler_dispatch is defined to help with type compilation
+
+
+class GUID(TypeDecorator):
+    """
+    A type for SQL Server's uniqueidentifier, stored as stringified UUIDs.
+    """
+
+    impl = CHAR
+
+    @property
+    def python_type(self) -> type[uuid.UUID]:
+        """The Python type for this SQL type is `uuid.UUID`."""
+        return uuid.UUID
+
+    @classmethod
+    def _compiler_dispatch(cls, _visitor: Visitable, **_kw: Any) -> str:
+        """Return the SQL type for the GUID type, which is CHAR(36) in SQL Server."""
+        return "CHAR(36)"
+
+    def process_bind_param(self, value: str, dialect: Dialect) -> Optional[str]:
+        """Prepare the UUID value for binding to the database."""
+        if value is None:
+            return None
+        if not isinstance(value, uuid.UUID):
+            return str(uuid.UUID(value))  # Convert to string UUID if needed
+        return str(value)
+
+    def process_result_value(
+        self, value: Optional[str], dialect: Dialect
+    ) -> Optional[uuid.UUID]:
+        """Convert the string back to a UUID when retrieving from the database."""
+        if value is None:
+            return None
+        return uuid.UUID(value)
diff --git a/tests/unit_tests/db_engine_specs/test_mssql.py b/tests/unit_tests/db_engine_specs/test_mssql.py
index 38a5603e4ec93..0a3760a47f1fa 100644
--- a/tests/unit_tests/db_engine_specs/test_mssql.py
+++ b/tests/unit_tests/db_engine_specs/test_mssql.py
@@ -27,6 +27,7 @@
 from sqlalchemy.types import String, TypeEngine, UnicodeText
 
 from superset.errors import ErrorLevel, SupersetError, SupersetErrorType
+from superset.models.sql_types.mssql_sql_types import GUID
 from superset.utils.core import GenericDataType
 from tests.unit_tests.db_engine_specs.utils import (
     assert_column_spec,
@@ -46,6 +47,7 @@
         ("NCHAR(10)", UnicodeText, None, GenericDataType.STRING, False),
         ("NVARCHAR(10)", UnicodeText, None, GenericDataType.STRING, False),
         ("NTEXT", UnicodeText, None, GenericDataType.STRING, False),
+        ("uniqueidentifier", GUID, None, GenericDataType.STRING, False),
     ],
 )
 def test_get_column_spec(