diff --git a/package-lock.json b/package-lock.json
index 36e2bc93bc05a..86cc1d6e283c4 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -3502,7 +3502,7 @@
 			"dependencies": {
 				"file-type": {
 					"version": "3.9.0",
-					"resolved": "https://registry.npmjs.org/file-type/-/file-type-3.9.0.tgz",
+					"resolved": "http://registry.npmjs.org/file-type/-/file-type-3.9.0.tgz",
 					"integrity": "sha1-JXoHg4TR24CHvESdEH1SpSZyuek=",
 					"dev": true,
 					"optional": true
@@ -4665,7 +4665,7 @@
 				},
 				"uuid": {
 					"version": "2.0.3",
-					"resolved": "https://registry.npmjs.org/uuid/-/uuid-2.0.3.tgz",
+					"resolved": "http://registry.npmjs.org/uuid/-/uuid-2.0.3.tgz",
 					"integrity": "sha1-Z+LoY3lyFVMN/zGOW/nc6/1Hsho=",
 					"dev": true,
 					"optional": true
@@ -4754,7 +4754,7 @@
 		},
 		"bl": {
 			"version": "1.2.2",
-			"resolved": "https://registry.npmjs.org/bl/-/bl-1.2.2.tgz",
+			"resolved": "http://registry.npmjs.org/bl/-/bl-1.2.2.tgz",
 			"integrity": "sha512-e8tQYnZodmebYDWGH7KMRvtzKXaJHx3BbilrgZCfvyLUYdKpK1t5PSPmpkny/SgiTSCnjfLW7v5rlONXVFkQEA==",
 			"dev": true,
 			"optional": true,
@@ -4940,7 +4940,7 @@
 		},
 		"browserify-aes": {
 			"version": "1.2.0",
-			"resolved": "https://registry.npmjs.org/browserify-aes/-/browserify-aes-1.2.0.tgz",
+			"resolved": "http://registry.npmjs.org/browserify-aes/-/browserify-aes-1.2.0.tgz",
 			"integrity": "sha512-+7CHXqGuspUn/Sl5aO7Ea0xWGAtETPXNSAjHo48JfLdPWcMng33Xe4znFvQweqc/uzk5zSOI3H52CYnjCfb5hA==",
 			"dev": true,
 			"requires": {
@@ -5092,14 +5092,14 @@
 			"dependencies": {
 				"file-type": {
 					"version": "3.9.0",
-					"resolved": "https://registry.npmjs.org/file-type/-/file-type-3.9.0.tgz",
+					"resolved": "http://registry.npmjs.org/file-type/-/file-type-3.9.0.tgz",
 					"integrity": "sha1-JXoHg4TR24CHvESdEH1SpSZyuek=",
 					"dev": true,
 					"optional": true
 				},
 				"uuid": {
 					"version": "2.0.3",
-					"resolved": "https://registry.npmjs.org/uuid/-/uuid-2.0.3.tgz",
+					"resolved": "http://registry.npmjs.org/uuid/-/uuid-2.0.3.tgz",
 					"integrity": "sha1-Z+LoY3lyFVMN/zGOW/nc6/1Hsho=",
 					"dev": true,
 					"optional": true
@@ -6007,7 +6007,7 @@
 			"dependencies": {
 				"cacache": {
 					"version": "10.0.4",
-					"resolved": "https://registry.npmjs.org/cacache/-/cacache-10.0.4.tgz",
+					"resolved": "http://registry.npmjs.org/cacache/-/cacache-10.0.4.tgz",
 					"integrity": "sha512-Dph0MzuH+rTQzGPNT9fAnrPmMmjKfST6trxJeK7NQuHRaVw24VzPRWTmg9MpcwOVQZO0E1FBICUlFeNaKPIfHA==",
 					"dev": true,
 					"requires": {
@@ -7471,7 +7471,7 @@
 		},
 		"duplexer": {
 			"version": "0.1.1",
-			"resolved": "https://registry.npmjs.org/duplexer/-/duplexer-0.1.1.tgz",
+			"resolved": "http://registry.npmjs.org/duplexer/-/duplexer-0.1.1.tgz",
 			"integrity": "sha1-rOb/gIwc5mtX0ev5eXessCM0z8E=",
 			"dev": true
 		},
@@ -10755,7 +10755,7 @@
 			"dependencies": {
 				"async": {
 					"version": "0.2.10",
-					"resolved": "https://registry.npmjs.org/async/-/async-0.2.10.tgz",
+					"resolved": "http://registry.npmjs.org/async/-/async-0.2.10.tgz",
 					"integrity": "sha1-trvgsGdLnXGXCMo43owjfLUmw9E=",
 					"dev": true
 				},
@@ -10915,7 +10915,7 @@
 				},
 				"uglify-js": {
 					"version": "2.7.5",
-					"resolved": "https://registry.npmjs.org/uglify-js/-/uglify-js-2.7.5.tgz",
+					"resolved": "http://registry.npmjs.org/uglify-js/-/uglify-js-2.7.5.tgz",
 					"integrity": "sha1-RhLAx7qu4rp8SH3kkErhIgefLKg=",
 					"dev": true,
 					"requires": {
@@ -10927,7 +10927,7 @@
 				},
 				"yargs": {
 					"version": "3.10.0",
-					"resolved": "https://registry.npmjs.org/yargs/-/yargs-3.10.0.tgz",
+					"resolved": "http://registry.npmjs.org/yargs/-/yargs-3.10.0.tgz",
 					"integrity": "sha1-9+572FfdfB0tOMDnTvvWgdFDH9E=",
 					"dev": true,
 					"requires": {
@@ -16884,7 +16884,7 @@
 			"dependencies": {
 				"progress": {
 					"version": "1.1.8",
-					"resolved": "https://registry.npmjs.org/progress/-/progress-1.1.8.tgz",
+					"resolved": "http://registry.npmjs.org/progress/-/progress-1.1.8.tgz",
 					"integrity": "sha1-4mDHj2Fhzdmw5WzD4Khd4Xx6V74=",
 					"dev": true
 				}
diff --git a/src/wp-admin/admin-ajax.php b/src/wp-admin/admin-ajax.php
index 7d9266d80f802..deea44152c240 100644
--- a/src/wp-admin/admin-ajax.php
+++ b/src/wp-admin/admin-ajax.php
@@ -53,6 +53,7 @@
 	'autocomplete-user',
 	'dashboard-widgets',
 	'logged-in',
+	'rest-nonce',
 );
 
 $core_actions_post = array(
diff --git a/src/wp-admin/includes/ajax-actions.php b/src/wp-admin/includes/ajax-actions.php
index 8d10ff731dad9..17f02438977e4 100644
--- a/src/wp-admin/includes/ajax-actions.php
+++ b/src/wp-admin/includes/ajax-actions.php
@@ -5268,3 +5268,12 @@ function wp_ajax_health_check_get_sizes() {
 
 	wp_send_json_success( $all_sizes );
 }
+
+/**
+ * Ajax handler to renew the REST API nonce.
+ *
+ * @since 5.3.0
+ */
+function wp_ajax_rest_nonce() {
+	exit( wp_create_nonce( 'wp_rest' ) );
+}
diff --git a/src/wp-includes/script-loader.php b/src/wp-includes/script-loader.php
index 5d1e891a3eb94..85bee7d388b0c 100644
--- a/src/wp-includes/script-loader.php
+++ b/src/wp-includes/script-loader.php
@@ -651,26 +651,19 @@ function wp_default_packages_inline_scripts( &$scripts ) {
 	}
 	$scripts->add_inline_script(
 		'wp-api-fetch',
-		sprintf(
-			implode(
-				"\n",
-				array(
-					'( function() {',
-					'	var nonceMiddleware = wp.apiFetch.createNonceMiddleware( "%s" );',
-					'	wp.apiFetch.use( nonceMiddleware );',
-					'	wp.hooks.addAction(',
-					'		"heartbeat.tick",',
-					'		"core/api-fetch/create-nonce-middleware",',
-					'		function( response ) {',
-					'			if ( response[ "rest_nonce" ] ) {',
-					'				nonceMiddleware.nonce = response[ "rest_nonce" ];',
-					'			}',
-					'		}',
-					'	);',
-					'} )();',
-				)
+		join(
+			array(
+				sprintf(
+					'wp.apiFetch.nonceMiddleware = wp.apiFetch.createNonceMiddleware( "%s" );',
+					( wp_installing() && ! is_multisite() ) ? '' : wp_create_nonce( 'wp_rest' )
+				),
+				'wp.apiFetch.use( wp.apiFetch.nonceMiddleware );',
+				sprintf(
+					'wp.apiFetch.nonceEndpoint = "%s";',
+					admin_url( 'admin-ajax.php?action=rest-nonce' )
+				),
 			),
-			( wp_installing() && ! is_multisite() ) ? '' : wp_create_nonce( 'wp_rest' )
+			"\n"
 		),
 		'after'
 	);