diff --git a/pandas/core/series.py b/pandas/core/series.py
index 83f80c305c5eb..7c1192374fc44 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -2324,9 +2324,11 @@ def combine(self, other, func, fill_value=None):
         elif is_extension_array_dtype(self.values):
             # The function can return something of any type, so check
             # if the type is compatible with the calling EA
+            # ExtensionArray._from_sequence can raise anything, so we
+            # have to catch everything.
             try:
                 new_values = self._values._from_sequence(new_values)
-            except TypeError:
+            except Exception:
                 pass
 
         return self._constructor(new_values, index=new_index, name=new_name)
diff --git a/pandas/tests/extension/test_ops.py b/pandas/tests/extension/test_ops.py
new file mode 100644
index 0000000000000..5d23fc8bf899a
--- /dev/null
+++ b/pandas/tests/extension/test_ops.py
@@ -0,0 +1,20 @@
+import operator
+from decimal import Decimal
+
+import pandas as pd
+import pandas.util.testing as tm
+from pandas.tests.extension.decimal.array import DecimalArray
+
+
+def test_combine_from_sequence_raises():
+    # https://github.com/pandas-dev/pandas/issues/22850
+    class BadDecimalArray(DecimalArray):
+        def _from_sequence(cls, scalars, dtype=None, copy=False):
+            raise KeyError("For the test")
+
+    ser = pd.Series(BadDecimalArray([Decimal("1.0"), Decimal("2.0")]))
+    result = ser.combine(ser, operator.add)
+
+    # note: object dtype
+    expected = pd.Series([Decimal("2.0"), Decimal("4.0")], dtype="object")
+    tm.assert_series_equal(result, expected)