diff --git a/pkgs/development/libraries/s2n-tls/default.nix b/pkgs/development/libraries/s2n-tls/default.nix
index c22ff6c37309d..e6e35f9b2c421 100644
--- a/pkgs/development/libraries/s2n-tls/default.nix
+++ b/pkgs/development/libraries/s2n-tls/default.nix
@@ -25,6 +25,9 @@ stdenv.mkDerivation rec {
     "-DBUILD_SHARED_LIBS=ON"
     "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DUNSAFE_TREAT_WARNINGS_AS_ERRORS=OFF" # disable -Werror
+  ] ++ lib.optionals stdenv.hostPlatform.isMips64 [
+    # See https://github.com/aws/s2n-tls/issues/1592 and https://github.com/aws/s2n-tls/pull/1609
+    "-DS2N_NO_PQ=ON"
   ];
 
   propagatedBuildInputs = [ openssl ]; # s2n-config has find_dependency(LibCrypto).