Skip to content

Latest commit

 

History

History
86 lines (66 loc) · 3.03 KB

README.md

File metadata and controls

86 lines (66 loc) · 3.03 KB
Raw

GenotypeTensors

This project provides tools to load the vectorized genotype information files (.vec/.vecp) produced with goby3 and variationanalysis. It also demonstrates how to train deep-learning models using information in these files with pytorch.

Installation

GenotypeTensors has been upgraded to pytorch 0.4.0.

on windows:

conda create --name pytorch4
conda install pytorch -c pytorch
miniconda/Scripts/activate.bat pytorch4

Use the pip.exe in miniconda for the following.

on mac:

conda install pytorch torchvision -c pytorch

Common to all platforms:

pip install -r requirements.txt

Example Training

Assuming you have downloaded a training dataset called dataset-2018-01-16 (with files dataset-2018-01-16-train.vec*, dataset-2018-01-16-validation.vec*), you can run the following to train an auto-encoder:

bin/train-autoencoder.sh --mode autoencoder \
        --problem genotyping:dataset-2018-01-16 \
        --lr 0.001  \
        --L2 1E-6   \
        --mini-batch-size 128 \
        --checkpoint-key GENOTYPE_AUTOENCODER_1 \
        --max-epochs 20

The model will be trained for 20 epochs. Best models are saved as checkpoints under the checkpoint directory, using the provided --checkpoint-key.

You can monitor the performance metrics during training with these files:

  • all-perfs-GENOTYPE_AUTOENCODER_1.tsv
  • best-perfs-GENOTYPE_AUTOENCODER_1.tsv (restricted to performance of best models, up to latest training epoch.)
  • args-GENOTYPE_AUTOENCODER_1 (contains exact command line used to train the model, useful for reproducing previous runs, includes random seed)

If you do not provide --checkpoint-key argument, a random one is generated and saved in args-*. This is convenient to perform hyperparameter searches.

Training somatic models

Instead of training an auto-encoder, the code base also supports training a model to call somatic mutations. The vec files must have been created with a somatic feature mapper and in this case, you can do:

bin/train-autoencoder.sh --mode supervised_somatic \
        --problem somatic:dataset2-2018-01-17 \
        --lr 0.001  \
        --L2 1E-6   \
        --mini-batch-size 128 \
        --checkpoint-key GENOTYPE_AUTOENCODER_1 \
        --max-epochs 20

Note that we changed both the mode (now supervised_somatic) and the the dataset, now somatic:dataset2. Training a somatic supervised model requires specific outputs in the .vec files, which are produced by somatic feature mappers in the variationanalysis project (and by the DNANexus Convert Somatic .sbi to Tensors app).

Training genotyping models with semi-supervised training:

bin/train-autoencoder.sh --mode semisupervised_genotypes \
                --problem genotyping:/data/gen/CNG-NA12878-realigned-2018-01-30 \
                --lr 0.01 --L2 1E-6 --mini-batch-size 100 \
                --checkpoint-key GENOTYPE_SEMISUP_1 \
                --max-epochs 200 -n 500 -x 10000