diff --git a/library/core/src/slice/mod.rs b/library/core/src/slice/mod.rs
index 6d3e625bef428..8d87e17cb2392 100644
--- a/library/core/src/slice/mod.rs
+++ b/library/core/src/slice/mod.rs
@@ -9,7 +9,7 @@
 use crate::cmp::Ordering::{self, Equal, Greater, Less};
 use crate::fmt;
 use crate::hint;
-use crate::intrinsics::{exact_div, unchecked_sub};
+use crate::intrinsics::{exact_div, select_unpredictable, unchecked_sub};
 use crate::mem::{self, SizedTypeProperties};
 use crate::num::NonZero;
 use crate::ops::{Bound, OneSidedRange, Range, RangeBounds};
@@ -2787,41 +2787,54 @@ impl<T> [T] {
     where
         F: FnMut(&'a T) -> Ordering,
     {
-        // INVARIANTS:
-        // - 0 <= left <= left + size = right <= self.len()
-        // - f returns Less for everything in self[..left]
-        // - f returns Greater for everything in self[right..]
         let mut size = self.len();
-        let mut left = 0;
-        let mut right = size;
-        while left < right {
-            let mid = left + size / 2;
-
-            // SAFETY: the while condition means `size` is strictly positive, so
-            // `size/2 < size`. Thus `left + size/2 < left + size`, which
-            // coupled with the `left + size <= self.len()` invariant means
-            // we have `left + size/2 < self.len()`, and this is in-bounds.
+        if size == 0 {
+            return Err(0);
+        }
+        let mut base = 0usize;
+
+        // This loop intentionally doesn't have an early exit if the comparison
+        // returns Equal. We want the number of loop iterations to depend *only*
+        // on the size of the input slice so that the CPU can reliably predict
+        // the loop count.
+        while size > 1 {
+            let half = size / 2;
+            let mid = base + half;
+
+            // SAFETY: the call is made safe by the following inconstants:
+            // - `mid >= 0`: by definition
+            // - `mid < size`: `mid = size / 2 + size / 4 + size / 8 ...`
             let cmp = f(unsafe { self.get_unchecked(mid) });
 
-            // This control flow produces conditional moves, which results in
-            // fewer branches and instructions than if/else or matching on
-            // cmp::Ordering.
-            // This is x86 asm for u8: https://rust.godbolt.org/z/698eYffTx.
-            left = if cmp == Less { mid + 1 } else { left };
-            right = if cmp == Greater { mid } else { right };
-            if cmp == Equal {
-                // SAFETY: same as the `get_unchecked` above
-                unsafe { hint::assert_unchecked(mid < self.len()) };
-                return Ok(mid);
-            }
-
-            size = right - left;
+            // Binary search interacts poorly with branch prediction, so force
+            // the compiler to use conditional moves if supported by the target
+            // architecture.
+            base = select_unpredictable(cmp == Greater, base, mid);
+
+            // This is imprecise in the case where `size` is odd and the
+            // comparison returns Greater: the mid element still gets included
+            // by `size` even though it's known to be larger than the element
+            // being searched for.
+            //
+            // This is fine though: we gain more performance by keeping the
+            // loop iteration count invariant (and thus predictable) than we
+            // lose from considering one additional element.
+            size -= half;
         }
 
-        // SAFETY: directly true from the overall invariant.
-        // Note that this is `<=`, unlike the assume in the `Ok` path.
-        unsafe { hint::assert_unchecked(left <= self.len()) };
-        Err(left)
+        // SAFETY: base is always in [0, size) because base <= mid.
+        let cmp = f(unsafe { self.get_unchecked(base) });
+        if cmp == Equal {
+            // SAFETY: same as the `get_unchecked` above.
+            unsafe { hint::assert_unchecked(base < self.len()) };
+            Ok(base)
+        } else {
+            let result = base + (cmp == Less) as usize;
+            // SAFETY: same as the `get_unchecked` above.
+            // Note that this is `<=`, unlike the assume in the `Ok` path.
+            unsafe { hint::assert_unchecked(result <= self.len()) };
+            Err(result)
+        }
     }
 
     /// Binary searches this slice with a key extraction function.
diff --git a/library/core/tests/slice.rs b/library/core/tests/slice.rs
index 4cbbabb672ba0..9f526a85e69d3 100644
--- a/library/core/tests/slice.rs
+++ b/library/core/tests/slice.rs
@@ -69,13 +69,13 @@ fn test_binary_search() {
     assert_eq!(b.binary_search(&8), Err(5));
 
     let b = [(); usize::MAX];
-    assert_eq!(b.binary_search(&()), Ok(usize::MAX / 2));
+    assert_eq!(b.binary_search(&()), Ok(usize::MAX - 1));
 }
 
 #[test]
 fn test_binary_search_by_overflow() {
     let b = [(); usize::MAX];
-    assert_eq!(b.binary_search_by(|_| Ordering::Equal), Ok(usize::MAX / 2));
+    assert_eq!(b.binary_search_by(|_| Ordering::Equal), Ok(usize::MAX - 1));
     assert_eq!(b.binary_search_by(|_| Ordering::Greater), Err(0));
     assert_eq!(b.binary_search_by(|_| Ordering::Less), Err(usize::MAX));
 }
@@ -87,13 +87,13 @@ fn test_binary_search_implementation_details() {
     let b = [1, 1, 2, 2, 3, 3, 3];
     assert_eq!(b.binary_search(&1), Ok(1));
     assert_eq!(b.binary_search(&2), Ok(3));
-    assert_eq!(b.binary_search(&3), Ok(5));
+    assert_eq!(b.binary_search(&3), Ok(6));
     let b = [1, 1, 1, 1, 1, 3, 3, 3, 3];
     assert_eq!(b.binary_search(&1), Ok(4));
-    assert_eq!(b.binary_search(&3), Ok(7));
+    assert_eq!(b.binary_search(&3), Ok(8));
     let b = [1, 1, 1, 1, 3, 3, 3, 3, 3];
-    assert_eq!(b.binary_search(&1), Ok(2));
-    assert_eq!(b.binary_search(&3), Ok(4));
+    assert_eq!(b.binary_search(&1), Ok(3));
+    assert_eq!(b.binary_search(&3), Ok(8));
 }
 
 #[test]